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MassIVE MSV000100505 - Untargeted LC MSMS metabolomics of mdx mouse skeletal muscleneg_mgf
Alex Dias Assis
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Humanin improves bone health in a glucocorticoid-treated mouse model of Duchenne muscular dystrophy. [PDF]
Cedervall T +7 more
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Neuromuscular transmission in the mdx mouse
Muscle & Nerve, 1990AbstractThe mdx mouse is an animal model for human Duchenne dystrophy. In both disorders, the muscle fiber plasma membrane is rendered selectively vulnerable by dystrophin deficiency. In both disorders there are also ultrastructural abnormalities involving the postsynaptic membrane of the neuromuscular junction.
A, Nagel, F, Lehmann-Horn, A G, Engel
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Muscular weakness in the mdx mouse
Journal of the Neurological Sciences, 1993mdx mice are believed to be virtually free from neuromuscular symptoms, despite the presence of a degenerative/regenerative process that involves all skeletal muscles. We analyzed both the spontaneous motility and treadmill motor activity of mdx mice aged 15 days to 6 months.
Muntoni F. +4 more
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Axonal transport in mdx mouse sciatic nerve
Journal of the Neurological Sciences, 1989Anterograde and retrograde flows of acetylcholinesterase (AChE) in sciatic nerves of adult mdx mice were compared with those of normal mice. Specific molecular forms of AChE were resolved by high-performance liquid chromatography such that slow anterograde (G1 + G2), fast anterograde and fast retrograde (G4 and A12) flows could be simultaneously ...
S, Yamashita +6 more
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Twitch and tetanus in mdx mouse muscle
Muscle & Nerve, 1992AbstractWe compared mdx and C57BL10 anterior tibial muscle force in situ (single pulse, multiple pulse, staircase, posttetanic potentiation, and fatiguing stimulation patterns) to define muscle strength, physiology, and fatigue resistance. The relatively hypertrophied mdx muscle showed: reduced strength (N/cm2), an increased twitch‐tetanus ratio, and ...
J G, Quinlan +3 more
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Prostaglandin metabolism in dystrophin-deficient MDX mouse muscle
Biochemical Society Transactions, 1991An accumulation of intracellular calcium has been implicated in the processes of damage to dystrophic muscle (1-31. Previous studies have also indicated calcium-induced damage to normal skeletal muscle in associated with a release of prostaglandins EZ and F2a [4] and that inhibition of phospholipase enzymes reduces some of the features of muscle damage
A, McArdle +3 more
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Passive avoidance behaviour deficit in the mdx mouse
Neuromuscular Disorders, 1991Thirty per cent of boys with Duchenne muscular dystrophy (DMD) suffer from various degrees of mental retardation. Since dystrophin, the protein absent in muscles of boys with DMD, is produced also in the brain, it was postulated that the deficiency of brain dystrophin might account for the mental retardation found in DMD boys.
Muntoni F., Mateddu A., SERRA, Gino
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P.1.18 NMR imaging comparison of dystrophic mouse models: mdx, Large, mdx/Large
Neuromuscular Disorders, 2013The mdx is the mouse model for Duchenne muscular dystrophy (MD), but with a benign phenotype. The large-myd mouse (Lg) has a mutation in the glycosyltransferase like Large gene and models the Congenital MD 1D, with a severe phenotype. The double mutant mdx/Lg, developed in our lab (1), has a more severe phenotype than both parental lineages. Dystrophic
A.B. Martins-Bach +8 more
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