Results 181 to 190 of about 9,256 (223)

Postnatal changes in sarcolemmal organization in the mdx mouse

Neuromuscular Disorders, 2005
The tibialis anterior muscles of mdx mice degenerate between 3 and 4 weeks after birth and then partially recover. We show that the membrane cytoskeleton at the mdx sarcolemma is disorganized at 18-days postnatal, and becomes more disorganized at 4 weeks compared to earlier or later times.
Patrick, Reed, Robert J, Bloch
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Pre-clinical screening of drugs using the mdx mouse

Neuromuscular Disorders, 2000
The genetically dystrophin-deficient mdx mouse, with its characteristic and regular exercise-induced loss of strength, is a useful experimental platform on which to screen potential drug therapies in the treatment of some dystrophic diseases. Pharmacological agents of several chemical and functional classes were examined in their ability to reduce the ...
J A, Granchelli, C, Pollina, M S, Hudecki   +2 more
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ELECTROMYOGRAPHIC AND NERVE CONDUCTION STUDIES IN THE mdx MOUSE

American Journal of Physical Medicine & Rehabilitation, 1992
Electromyographic responses to needle-electrode insertion and repetitive indirect stimulation were recorded from gastrocnemius, soleus and cranial tibialis muscles of normal and dystrophic (mdx) mice at 20-154 days. Recordings from myotonic (ADRmto) mice served as controls for "true" myotonia.
G T, Carter, K J, Longley, R K, Entrikin
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Molecular forms of acetylcholinesterase in dystrophic (mdx) mouse tissues

Neuromuscular Disorders, 1992
We analyzed the activity of acetylcholinesterase (AChE) and its molecular forms in the tissues of normal and dystrophic (mdx) mice, at different developmental stages. We studied the brain, the heart and the serum, in addition to four predominantly fast-twitch muscles (tibialis, plantaris, gastrocnemius and extensor digitorum longus (EDL)) and the slow ...
Oliver, Lisa, Chatel, Jean-Marc, Massoulié, Jean, Vigny, Marc, Vallette, François   +4 more
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THE mdx MOUSE SKELETAL MUSCLE MYOPATHY: II. CONTRACTILE PROPERTIES

Neuropathology and Applied Neurobiology, 1988
The mdx mouse skeletal muscle myopathy: II. Contractile propertiesThe contractile properties of soleus muscles from mdx and control mice aged between 26 and 350 days were compared with those of muscles from similarly aged control mice. Mdx mice were in general heavier (their individual soleus muscles were also heavier), of greater cross–sectional area ...
G R, Coulton, N A, Curtin, J E, Morgan, T A, Partridge   +3 more
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Normal Cochlear Function in mdx and mdx^Cv3 Duchenne Muscular Dystrophy Mouse Models

The Laryngoscope, 1999
AbstractObjectives/Hypothesis: Sensorineural hearing loss has been found in association with inherited muscular dystrophies in humans and in mouse models. An increased brainstem auditory evoked response threshold has been previously reported in the dystrophin‐deficient mdx mouse model for Duchenne muscular dystrophy, suggesting that full‐length ...
D A, Pillers, N M, Duncan, S J, Dwinnell, S M, Rash, J B, Kempton, D R, Trune   +5 more
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Regeneratedmdxmouse skeletal muscle shows differential mRNA expression

Journal of Applied Physiology, 2002
Despite over 3,000 articles published on dystrophin in the last 15 years, the reasons underlying the progression of the human disease, differential muscle involvement, and disparate phenotypes in different species are not understood. The present experiment employed a screen of 12,488 mRNAs in 16-wk-old mouse mdx muscle at a time when the skeletal ...
B S, Tseng, P, Zhao, J S, Pattison, S E, Gordon, J A, Granchelli, R W, Madsen, L C, Folk, E P, Hoffman, F W, Booth   +8 more
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Assessing functional performance in the mdx mouse model.

Journal of visualized experiments : JoVE, 2014
Duchenne muscular dystrophy (DMD) is a severe and progressive muscle wasting disorder for which no cure is available. Nevertheless, several potential pharmaceutical compounds and gene therapy approaches have progressed into clinical trials. With improvement in muscle function being the most important end point in these trials, a lot of emphasis has ...
Aartsma-Rus, A., Putten, M. van
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Oxyradical Damage and Mitochondrial Enzyme Activities in the mdx Mouse

Neuropediatrics, 1995
A number of studies have already been undertaken to investigate involvement of oxyradicals in muscle diseases by means of measurements of oxyradical protective enzymes. We investigated o-tyrosine, which is a biomarker for OH radical damage in vivo, in 10 mdx and 10 control mice. We also measured mitochondrial enzymes in muscle homogenates of 10 mdx and
E, Hauser, H, Höger, R, Bittner, K, Widhalm, K, Herkner, G, Lubec   +5 more
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Force and stiffness of old dystrophic (mdx) mouse skeletal muscles

Muscle & Nerve, 1998
It has recently been suggested, based on studies of tissue pathology, that the limb muscles of old mdx mice may be a good model for the muscular changes seen in human Duchenne muscular dystrophy. To test this hypothesis, we measured force and stiffness of soleus and extensor digitorum longus (EDL) muscles of old (20-21 months) mdx mice and age-matched ...
J, Bobet, R F, Mooney, T, Gordon
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