Results 191 to 200 of about 9,256 (223)

Somatic reversion/suppression of the mouse mdx phenotype in vivo

Journal of the Neurological Sciences, 1990
The mdx mouse has a myopathy caused by dystrophin deficiency, and is therefore biochemically and genetically homologous to human Duchenne muscular dystrophy. While mdx mouse muscle shows no dystrophin by immunoblotting, a very small percentage of myofibers appear clearly dystrophin-positive by immunofluorescence microscopy.
E P, Hoffman, J E, Morgan, S C, Watkins, T A, Partridge   +3 more
openaire   +2 more sources

Evolution of the mdx mouse cardiomyopathy: physiological and morphological findings

Neuromuscular Disorders, 2004
Heart failure is a major cause of death in boys with Duchenne muscular dystrophy. In order to determine if the cardiac function of the mdx mouse is similarly disturbed, we performed murine echocardiograms and left heart catheterization studies, along with morphometric analysis of cardiac fibrosis.
John G, Quinlan, Harvey S, Hahn, Brenda L, Wong, John N, Lorenz, Alexandra S, Wenisch, Linda S, Levin   +5 more
openaire   +2 more sources

Radiation inhibition of mdx mouse muscle regeneration: Dose and age factors

Muscle & Nerve, 1995
AbstractA single hind limb was irradiated with 12, 18, 24, or 30 Gy in mdx and C57 mice aged 12, 21, or 42 days to determine regeneration inhibition dose‐response curves in different aged dystrophic mice and to characterize radiation side‐effects in normal mice.
J G, Quinlan, S P, Lyden, D M, Cambier, S R, Johnson, S E, Michaels, D L, Denman   +5 more
openaire   +2 more sources

Therapeutic screening in the mdx mouse

Neuromuscular Disorders, 2000
CONTE, Diana, DE LUCA, Annamaria
openaire   +3 more sources

DNA concentrations are increased in MDX mouse muscles

Biochemical Society Transactions, 1991
P A, MacLennan, M J, Jackson, R H, Edwards   +2 more
openaire   +2 more sources

Mdx mouse

Journal of the Neurological Sciences, 2002
openaire   +1 more source

Serum and organ indices of the mdx dystrophic mouse.

Research communications in chemical pathology and pharmacology, 1992
Duchenne muscular dystrophy (DMD) is a fatal disease for which there is no effective treatment. The cause of death in patients with DMD is often cardiovascular and pulmonary dysfunction. This clinical observation, combined with experimental findings, suggests that other non-muscle organ systems may be affected in the dystrophic disease state.
G A, Brazeau, M, Mathew, R K, Entrikin
openaire   +1 more source

Expanded encyclopaedias of DNA elements in the human and mouse genomes

Nature, 2020
Jessika Adrian, Michael A Beer, Bradley E Bernstein   +2 more
exaly  

Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease

Nature Medicine, 2020
Yingyue Zhou, Wilbur M Song, Amanda Swain   +2 more
exaly  

The cardiomyopathy in the mdx mouse

Journal of Molecular and Cellular Cardiology, 1988
openaire   +1 more source