Results 291 to 300 of about 1,201,079 (362)

Effects of High‐ and Low‐Fat Meals on the Bioavailability and Pharmacokinetics of Votoplam, a HTT Gene Splicing Modifier

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Votoplam is a novel, orally bioavailable, small molecule HTT gene splicing modifier that is being developed for the treatment of Huntington's disease. This was a single dose, open‐label, two‐period, crossover food effect study that evaluated the effect of high‐ and low‐fat meals on 20 mg votoplam in healthy participants. There was a washout of
Lucy Lee, Amy‐Lee Richards, Nageswara Reddy, Brian Beers, Lee Golden, Ronald Kong   +5 more
wiley   +1 more source

Culinary Medicine and Lifestyle Medicine and the Power of Nutrient-Rich Additions. [PDF]

Am J Lifestyle Med
Hanus A.
europepmc   +1 more source

A Phase 1, Randomized, Placebo‐Controlled, Multiple‐Dose, Double‐Blind Study to Evaluate and Compare the Pharmacokinetics and Safety of Rimegepant in Healthy Adult Japanese and Caucasian Individuals

Clinical Pharmacology in Drug Development, EarlyView.
Abstract This Phase 1, randomized, placebo‐controlled, double‐blind study assessed the pharmacokinetic profile of rimegepant (25, 75, or 150 mg once daily for 14 days) in healthy Japanese and Caucasian adults. Exposures were modestly increased in Japanese participants compared with Caucasian participants following a single dose of rimegepant (Day 1 ...
Rajinder Bhardwaj, Chay Ngee Lim, Yinhua Li, Kyle T. Matschke, Richard Bertz, Robert Croop, Jing Liu   +6 more
wiley   +1 more source

Effect of Feeding Cottonseed Meal With or Without NSP Enzymes on Growth Performance, Blood Biochemistry, Growth-Related Gene Expression, Intestinal Health and Economic Efficiency in Broilers. [PDF]

Vet Med Sci
Saleh AA, Elkhaiat IA, Mansour M, Genedy S, Alhotan RA, Hussein EOS, Galik B, Hakami H, Sami AS, Kamal MA, El-Shall NA, Fawzy S.   +11 more
europepmc   +1 more source

Reducing the Burden of Interaction Studies in Cancer Patients Using a Stable Isotopically Labeled Microtracer: A Proof‐of‐Concept Study with Alectinib

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional drug‐food interaction studies of oral anticancer agents have a high patient burden. A patient‐friendly alternative approach to studying food effects could be the use of stable isotopically labeled microtracers. A prospective, single‐center, open‐label, crossover, food effect study with the microtracer 2H6‐alectinib was conducted in patients
Ma Ida Mohmaed Ali, Lisa T. van der Heijden, Matthijs Tibben, Hilde Rosing, Raween Kalicharan, Gerrina Ruiter, Jos H. Beijnen, Hinke Huisman‐Siebinga, Alwin D. R. Huitema, Neeltje Steeghs   +9 more
wiley   +1 more source

Alanyl-Glutamine Attenuates Soybean Meal-Induced Intestinal Dysfunction and Growth Retardation in Largemouth Bass (<i>Micropterus salmoides</i>). [PDF]

Aquac Nutr
Wang X, Yue R, Wen J, Wu H, Zhou X, Chen Y, Luo L, Lin S, Ai Q, He Y, Zhao W.   +10 more
europepmc   +1 more source

Family's socioeconomic and demographic factors on elements of children's dental and oral health: A scoping review

Clinical and Experimental Dental Research, EarlyView.
Abstract Background Family plays a significant role in children's dental and oral health (DOH) elements, such as children's DOH knowledge and practice, the development of children's dental fear and anxiety (DFA), children's dental visits, and children's DOH status.
Wisnu Fadila, Mugia B. Rahardja, Puguh Prasetyoputra, Anne A. Suwargiani, Yanu E. Prasetyo, Eriska Riyanti   +5 more
wiley   +1 more source

Desat1-mediated lipid homeostasis mitigates 20E-induced lipotoxicity in blood-fed mosquitoes. [PDF]

Nat Commun
Sun P, Wang G, Yang B, Wang Y, Cui C, Dong L, Li Y, Zhou T, Li F, Wang S.   +9 more
europepmc   +1 more source

Mapping and Innovating Business Models of Food Hubs in Short Food Supply Chains

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Short food supply chains (SFSCs) offer sustainable alternatives to conventional food systems (CFSCs) but require effective intermediaries to scale and remain competitive. Food Hubs (FHs) serve this role by enhancing SFSC efficiency and market reach while upholding community‐oriented values. However, limited research has examined how FHs design
Marije Renkema‐Singh, Lea Fobbe, Per Hilletofth   +2 more
wiley   +1 more source

Phlebotomine sand fly vector distribution, seasonality, blood meal sources, and infection rates in cutaneous leishmaniasis endemic areas of Northeast Ethiopia. [PDF]

Sci Rep
Tesfaye M, Zeynudin A, Mekonnen Z, Gebresilassie A, Abamecha K, Yewhalaw D.   +5 more
europepmc   +1 more source