Results 21 to 30 of about 4,749,978 (243)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Area Measures for Differential Item and Test Functioning on the Logit Scale: Relationships to Linking Errors in the 2PL Model

Mathematics
Area measures for differential item functioning and differential test functioning are conventionally defined as functions of the difference in item response functions.
Alexander Robitzsch
doaj   +1 more source

Prolonged job strain reduces time-domain heart rate variability on both working and resting days among cardiovascular-susceptible nurses

International Journal of Occupational Medicine and Environmental Health, 2015
Introduction Modifications of hearth rate variability (HRV) constitute a marker of the autonomic nervous system (ANS) deregulation, a promising pathway linking job strain (JS) and cardiovascular diseases (CVD).
Rossana Borchini, Lorenza Bertù, Marco M. Ferrario, Giovanni Veronesi, Matteo Bonzini, Marco Dorso, Giancarlo Cesana   +6 more
doaj   +1 more source

On the jacobsthal, horadam and geometric mean sequences [PDF]

, 2016
This paper, in considering aspects of the geometric mean sequence, offers new results connecting Jacobsthal and Horadam numbers which are established and then proved independently.This paper, in considering aspects of the geometric mean sequence, offers ...
Rabago, Julius, F. T., Larcombe, Peter J.   +1 more
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

An improved mapping adaptation method from three-dimensional non-solid geological information models to numerical computational models

Frontiers in Built Environment
Three-dimensional (3D) geological information models and numerical computational models differ substantially in their representation objectives, geometric organization, parameter systems, and spatial scales, which makes direct conversion between the two ...
Ziyu Tao, Zhen Liu, Zhen Liu, Cuiying Zhou, Cuiying Zhou   +4 more
doaj   +1 more source

General Framework for Georeferencing and Interpretation of Multi-Resolution LiDAR Data for Fine-Scale Forest Inventory [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences
Accurate forest inventory is critical for sustainable management, ecological assessment, and biomass estimation. Combining near-proximal and proximal Light Detection and Ranging (LiDAR) data produces point clouds that fully capture the forest structure ...
H. Hanafy, S.-Y. Shin, A. M. Eissa, Y. Hany, S. Park, S. Fei, A. Habib   +6 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Superelliptic Quaternion Structures for Curve and Surface Generation in Differential Geometry

Mathematics
This paper develops a unified superelliptic quaternionic framework for the generation and differential geometric analysis of curves and surfaces in affine three-space.
Esra Parlak, Zehra Özdemir
doaj   +1 more source

New weighted geometric mean method to estimate the slope of measurement error model [PDF]

, 2014
This paper introduces a new weighted geometric mean (WG) estimator to fit regression line when both the response and explanatory variables are subject to measurement errors.
Saqr, Anwar, Khan, Shahjahan
core