Results 21 to 30 of about 4,499,827 (230)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Estimation of Standard Error, Linking Error, and Total Error for Robust and Nonrobust Linking Methods in the Two-Parameter Logistic Model

Stats
The two-parameter logistic (2PL) item response theory model is a statistical model for analyzing multivariate binary data. In this article, two groups are brought onto a common metric using the 2PL model using linking methods. The linking methods of mean–
Alexander Robitzsch
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Superelliptic Quaternion Structures for Curve and Surface Generation in Differential Geometry

Mathematics
This paper develops a unified superelliptic quaternionic framework for the generation and differential geometric analysis of curves and surfaces in affine three-space.
Esra Parlak, Zehra Özdemir
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

On the jacobsthal, horadam and geometric mean sequences [PDF]

, 2016
This paper, in considering aspects of the geometric mean sequence, offers new results connecting Jacobsthal and Horadam numbers which are established and then proved independently.This paper, in considering aspects of the geometric mean sequence, offers ...
Rabago, Julius, F. T., Larcombe, Peter J.   +1 more
core  

New weighted geometric mean method to estimate the slope of measurement error model [PDF]

, 2014
This paper introduces a new weighted geometric mean (WG) estimator to fit regression line when both the response and explanatory variables are subject to measurement errors.
Saqr, Anwar, Khan, Shahjahan
core   +1 more source

Particle Transport in Self-Affine Rough Rock Fractures: A CFD–DEM Analysis of Multiscale Flow–Particle Interactions

Fractal and Fractional
Understanding particle transport in rough-walled fractures is essential for predicting flow behavior, clogging, and permeability evolution in natural and engineered subsurface systems.
Junce Xu, Kangsheng Xue, Hai Pu, Xingji He   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source