Results 41 to 50 of about 9,800 (195)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The Effect of Response Style on Self-Reported Conscientiousness Across 20 Countries

, 2012
Mottus R, Allik J, Realo A, et al. The Effect of Response Style on Self-Reported Conscientiousness Across 20 Countries. Personality And Social Psychology Bulletin.
Feng, X, Bochaver, Aleksandra, Realo, A., Idris, F., Björklund, F., Kuppens, P., Laurinavicius, Alfredas, Katigbak, MS, Backstrom, Martin, Dahourou, Donatien, Kwiatkowska, Anna, Schug, J., Laurinavicius, A, Cisse, Daouda Dougoumale, Laurinavicius, A., Mastor, Kairul Anwar, Idris, F, Kuppens, P, Donatien Dahourou, D., Ah-Kion, J, Barry, Oumar, Katigbak, M. S., Cabrera, Helena F., Zecca, G, Riemann, Rainer, Hwang, H, Chen, SX, Amoussou-Yeye, D, Bjorklund, Fredrik, Allik, Jüri, Bhowon, U, Guan, Yanjun, Cabrera, HF, Johnson, W., Tseung-Wong, Caroline Ng; id_orcid, Mõttus, René; id_orcid, Mastor, K. A., Simpson, B, Zecca, G., Ah-Kion, J., Mottus, R, Tseung-Wong, Caroline Ng, Dahourou, D, Allik, Jueri, Church, A. Timothy, Bhowon, U., Barry, O., Rossier, J., Zecca, Gregory, Cissé, D., Barkauskiene, R., Amoussou-Yeye, Denis, Chen, S. X., Bhowon, Uma, Bjorklund, F, Allik, J, Bochaver, A, Riemann, R., Barkauskiene, R, Mastor, Khairul Anwar, Amoussou-Yéyé, D., Xiaohua Chen, Sylvia, Tseung, C. N., Johnson, Wendy, Katigbak, Marcia S, Kwiatkowska, A, Realo, A, Simpson, B., Tseung-Wong, CN, Chen, Sylvia Xiaohua, Cabrera, H. F., Riemann, Rainer ; https://orcid.org/, Cisse, DD, Bochaver, K., Johnson, W, Mottus, Rene, de Bruin, D., Idris, Fazilah, Schug, J, Hwang, H.-S., De Bruin, G, Kuppens, Peter, Feng, Xiaohang, Schug, Joanna, Bochaver, K, Ah-Kion, Jennifer, Hwang, Hyi Sung, Katigbak, Marcia S., Church, A Timothy, Matsumoto, D, Simpson, Brian, Guan, Y, Mastor, KA, Matsumoto, David, Church, A. T., Bochaver, Konstantin, Rossier, J, Hwang, HS, Bäckström, M., Realo, Anu, Church, AT, Allik, J., Hwang, Hyi-Sung, Riemann, R, Matsumoto, D., Barkauskiene, Rasa, de Bruin, Gideon, Kwiatkowska, A., Barry, O, Guan, Y., Mõttus, R., Backstrom, M, Bochaver, A., Feng, X., Rossier, Jerome, Cabrera, Helena F   +115 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

解构皮质酮在介导甲基汞与壶菌 (Bd) 对两栖动物生存影响中的双重作用

Wildlife Letters
Amphibians have suffered widespread declines caused by many interacting factors whose effects are often difficult to isolate. We used complementary analyses to decouple effects of methylmercury (MeHg) and amphibian chytrid fungus (Bd) on survival of ...
Brian J. Tornabene, Morgan P. Kain, Creagh W. Breuner, Collin A. Eagles‐Smith, Lisa A. Eby, Ross K. Hinderer, Kelly L. Smalling, Blake R. Hossack   +7 more
doaj   +1 more source

The asymptotic mean action and the asymptotic linking number for pseudo-rotations

, 2023
We establish that the asymptotic mean action and the asymptotic linking number of irrational pseudo-rotations remain well-defined everywhere and constant for every $C^{1}$ irrational pseudo-rotation that behaves as a rotation on the boundary.
Senior, David Bechara, Pirnapasov, Abror, Calvez, Patrice Le   +2 more
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Изменчивость клеточных популяций у сахарной свёклы при различных способах репродукции

Фактори експериментальної еволюції організмів, 2014
A goal of the presented paper was to analyze the variability of cell populations in different by origin and breeding methods materials. Methods. The following parameters of stomata guard cell populations were evaluated: average mean of chloroplasts ...
С. С. Юданова
doaj  

Geometric distance and semantic structure: A methodological innovation for mixed methods research with HUDAP and ATLAS.ti

Methodological Innovations
This article presents a rigorous and replicable methodological alternative for articulating quantitative and qualitative analyses within mixed-methods research, contributing to interpretive coherence by relating quantitative proximity structures to ...
Jimmy William Ramírez Cano, William Manuel Mora Penagos, Diego Mauricio Rivera Pinzón   +2 more
doaj   +1 more source