Results 31 to 40 of about 4,749,978 (243)

Smaller is better: nanobodies meet NMR

open access: yesFEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Phon Mean oral history recording

open access: yes, 2001
An audio recording of an oral history of Phon Mean about fleeing Cambodia with her family at age ten and coming to the United States. She talks about life in Cambodia when she was a child and then about life in the U.S., including school, her first job ...
Mean, Phon
core   +1 more source

Particle Transport in Self-Affine Rough Rock Fractures: A CFD–DEM Analysis of Multiscale Flow–Particle Interactions

open access: yesFractal and Fractional
Understanding particle transport in rough-walled fractures is essential for predicting flow behavior, clogging, and permeability evolution in natural and engineered subsurface systems.
Junce Xu   +3 more
doaj   +1 more source

On two derivative sequences from scaled geometric mean sequence terms. [PDF]

open access: yes, 2018
The so called geometric mean sequence recurrence, with additional scaling variable, produces a sequence for which the general term has a known closed form. Two types of derivative sequence—comprising products of such sequence terms—are examined.
Rabago, Julius, F. T.   +2 more
core  

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

open access: yesMolecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David   +12 more
wiley   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

open access: yesMolecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Architectural features and symbolic roles of Binh Phong in Hue’s communal houses

open access: yesTạp chí Khoa học và Công nghệ
Dinh (Vietnamese communal houses) are central to village life, and in Hue they preserve vernacular layouts where the Binh Phong (screen) is a defining yet understudied feature.
Nguyen Ngoc Tung   +5 more
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

open access: yesMolecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna   +8 more
wiley   +1 more source

Modeling Soil Penetration Resistance Using Regression, Artificial Neural Network and Gene Expression Programming [PDF]

open access: yesمجله آب و خاک
IntroductionThe penetration resistance (PR) of the soil shows the mechanical resistance of the soil against the penetration of a conical or flat probe; it is important in terms of seed germination, root growth and tillage operations.
Sh. Asghari   +2 more
doaj   +1 more source

De novo synthesis of short‐chain aldehydes and hydrocarbons secreted by the brown marmorated stink bug Halyomorpha halys

open access: yesFEBS Open Bio, EarlyView.
The brown marmorated stink bug, Halyomorpha halys, mainly secretes 4‐oxo‐(E)‐2‐hexenal, (E)‐2‐decenal, dodecane and tridecane, a mixture representative of that released by many heteropterans. We demonstrated that H. halys can synthesise these secretory components de novo using dietary glucose.
Haruna Fujimori, Koji Noge
wiley   +1 more source

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