Results 81 to 90 of about 525,905 (280)
Mean curvature blow up in mean curvature flow
, 2009 In this note we establish that finite-time singularities of the mean curvature flow of compact Riemannian submanifolds are characterised by the blow up of the mean curvature.
openaire +2 more sources
Graphs with Parallel Mean Curvature [PDF]
Proceedings of the American Mathematical Society, 1989 We prove that if the graph Γ f = { ( x , f ( x ) ) :
openaire +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Ground state solutions for the Hénon prescribed mean curvature equation
Advances in Nonlinear Analysis, 2018 In this paper, we consider the analogous of the Hénon equation for the prescribed mean curvature problem in ℝN{{\mathbb{R}^{N}}}, both in the Euclidean and in the Minkowski spaces. Motivated by the studies of Ni and Serrin [W. M. Ni and J.
Azzollini Antonio
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Rotational Hypersurfaces in S3(r)R Product Space
Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2017 We consider rotational hypersurfaces in S3(r) R product space of five dimensional Euclidean space E5. We calculate the mean curvature and the Gaussian curvature, and give some results.
Erhan Güler, Ömer Kişi
doaj +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Gyroids of Constant Mean Curvature [PDF]
Experimental Mathematics, 1997 We use Brakke's Surface Evolver to deform a triply periodic minimal surface, the gyroid, into a continuous family of constant mean curvature surfaces with the same symmetry. We discuss stability and bifurcation problems for these surfaces.
openaire +2 more sources