Results 81 to 90 of about 5,469,641 (325)

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

open access: yesFEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer   +7 more
wiley   +1 more source

A survey on Inverse mean curvature flow in ROSSes

open access: yesComplex Manifolds, 2017
In this survey we discuss the evolution by inverse mean curvature flow of star-shaped mean convex hypersurfaces in non-compact rank one symmetric spaces.
Pipoli Giuseppe
doaj   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

open access: yesFEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur   +5 more
wiley   +1 more source

The prescribed mean curvature equation in weakly regular domains [PDF]

open access: yes, 2016
We show that the characterization of existence and uniqueness up to vertical translations of solutions to the prescribed mean curvature equation, originally proved by Giusti in the smooth case, holds true for domains satisfying very mild regularity ...
G. P. Leonardi, Giorgio Saracco
semanticscholar   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

MCnet: A Neural Network Method for Mean Curvature Optimization on Image Surfaces

open access: yesIEEE Access
Mean curvature is fundamentally important for various research fields, including differential geometry in mathematics, cell membrane modeling in biophysics and image processing in computer vision.
Zhili Wei, Wenming Tang, Yuanhao Gong
doaj   +1 more source

On stable constant mean curvature surfaces with free boundary [PDF]

open access: yes, 2016
Ros and Vergasta (Geom Dedicata 56:19–33, 1995) proved, among others interesting results, a theorem which states that an immersed orientable compact stable constant mean curvature surface $$\Sigma $$Σ with free boundary in a closed ball $$B\subset ...
Ivaldo Nunes
semanticscholar   +1 more source

CCT4 promotes tunneling nanotube formation

open access: yesFEBS Letters, EarlyView.
Tunneling nanotubes (TNTs) are membranous tunnel‐like structures that transport molecules and organelles between cells. They vary in thickness, and thick nanotubes often contain microtubules in addition to actin fibers. We found that cells expressing monomeric CCT4 generate many thick TNTs with tubulin.
Miyu Enomoto   +3 more
wiley   +1 more source

Constant Mean Curvature Spacelike Surfaces in Lorentzian Warped Products

open access: yesAdvances in Mathematical Physics, 2015
We characterize the spacelike slices of a Lorentzian warped product as the only constant mean curvature spacelike surfaces under suitable geometrical and physical assumptions.
Juan A. Aledo, Rafael M. Rubio
doaj   +1 more source

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