Results 91 to 100 of about 428,360 (302)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Limiting Behaviour Of The Mean Residual Life

, 2007
In survival or reliability studies, the mean residual life or life expectancy is an important characteristic of the model. Here, we study the limiting behaviour of the mean residual life, and derive an asymptotic expansion which can be used to obtain a ...
David M. Bradley, Ramesh C. Gupta, David Bradley And   +2 more
core  

Mean residual life order of convolutions of heterogeneous exponential random variables

, 2009
In this paper, we study convolutions of heterogeneous exponential random variables with respect to the mean residual life order. By introducing a new partial order (reciprocal majorization order), we prove that this order between two parameter vectors ...
N. Balakrishnan, Balakrishnan, N., Peng Zhao, Zhao, Peng   +3 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The relative tail of longevity and the mean remaining lifetime [PDF]

Vaupel (1998) posed the provocative question, “When it comes to death, how do people and flies differ from Toyotas?†He suggested that as the force of natural selection diminishes with age, structural reliability concepts can be profitably used in ...
James W. Vaupel, Maxim Finkelstein
core  

Combination of mean residual life order with reliability applications

Statistical Methodology, 2016
This paper has been withdrawn by the author due to a crucial sign error in equation ...
M. Kayid, S. Izadkhah, H. Alhalees
openaire   +2 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Relation between characyeristics of low-cycle and high-cycle fatigue of threaded parts and residual stresses

Вестник Самарского университета: Аэрокосмическая техника, технологии и машиностроение, 2018
The dependence of low-cycle and high-cycle fatigue characteristics of threaded parts on the criterion of average integral residual stresses is examined in the article.
A. S. Zlobin
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Mean residual life of kth records under double monitoring

, 2014
In the study of reliability of technical systems and shock models, the mean residual life function plays an important role. In this paper, we consider the mean residual life of kth records under double monitoring.
Nur Munawwarah
core