Results 51 to 60 of about 1,360,767 (269)

Assessing Reliability in Manufacturing Systems by a New Arrangement of the Mean Time Between Failures (MTBF)

مجلة النهرين للعلوم الهندسية
This work has studied the size of the mean time between failures (MTBF) because it has a vital role in assessing reliability in manufacturing systems.
Abdulkhalek M. Kadir
doaj   +1 more source

Efficient estimation of the mean time between failures in non-regenerative dependability models [PDF]

Proceedings of the 25th conference on Winter simulation - WSC '93, 1993
In this paper we discuss fast simulation techniques for estimating the steady-state mean time between failures (MTBF) in non-Markovian models of highly dependable systems. The key is to use a ratio representation of the MTBF, in which the denominator is closely related to the probability of a rare event and is therefore amenable to estimation using ...
Glynn, P.W., Heidelberger, P., Nicola, Victor F., Shahabuddin, P.   +3 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Reliability Analysis Considering the PFC Function and Redundancy Effect of the Vienna Converter

IEEE Access
This paper analyzes the impact of power factor correction (PFC) on the failure rate of a Vienna converter through reliability analysis under conditions where AC-to-DC conversion is possible but the PFC function is not functioning due to a partial failure
Yun-Sik Jang, Sang-Hyeok Lee, Feel-Soon Kang   +2 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Temporal trends and reliability of computed tomography scanner failures: evidence from a real-world time-series analysis

Frontiers in Physics
ObjectiveWe aimed to characterize temporal and component-specific patterns of CT malfunctions and identifying optimal monitoring intervals are critical to strengthening preventive maintenance and informed equipment management.MethodsThis study collected ...
Xiaoxiao Luan, Sujuan Yu, Shaohua Yin, Zhenlin Liu, Dongxu Wang, Ying Xiao, Ruoyao Pan, Boqi Jia, Feng Xu, Yun Tian, Yun Tian, Rong Li   +11 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Self‐Reported Outdoor Light Exposure Time and Incident Heart Failure

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background A healthy lifestyle is an important factor for preventing heart failure. However, the association between outdoor light exposure time and heart failure is still unknown.
Ziteng Zhang, Bowei Yu, Ying Sun, Kun Zhang, Xiao Tan, Yingli Lu, Ningjian Wang, Fangzhen Xia   +7 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source