Results 91 to 100 of about 984,374 (339)

Listen while you work: negotiating power and meaning in post-concrete music. [PDF]

open access: yes
Following the radical affordances of the then-recent technologies the microphone and tape, Musique Concrète proposed that all sound could now become music.
Herbert, M.
core  

Seeing-as and reading-in: an inquiry into imagination and meaning in aesthetics [PDF]

open access: yes, 2010
Words and pictures both bear meanings, but they cannot be substituted for one another. When we discuss the meanings of visual and literary works of art we often stumble upon this problem. Underlying our compulsion to ―translate‖ the meaning of visual art
Ham, Alexandria Stacy
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Improving wellbeing at work

open access: yes, 2015
The article discusses the importance of workplace wellbeing strategies in order to improve workplace performance. Also cited are the adverse effects of a weak psychosocial environment like eliciting negative coping strategies, the meaning of wellbeing at
Brownett, T.
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Me, myself and I: identity and meaning in the lives of vulnerable young people [PDF]

open access: yes, 2013
Questions relating to identity and meaning are fundamental questions of life. As such, they have been the subject of study by scholars across a diverse range of disciplines, including psychology, theology, sociology and philosophy, throughout history ...
Debbie Noble-Carr   +2 more
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Meaning-making processes among bereaved mothers who have lost a child to cancer

open access: yes, 2007
Includes bibliographical references (leaves 86-93).The loss of a child constitutes a crisis of meaning, as prior meaning structures and fundamental assumptions about the world are shattered, and the natural order of life and death is undennined ...
Lipshitz, Marc
core  

Returning to work following cancer: a qualitative exploratory study into the experience of returning to work following cancer [PDF]

open access: yes, 2007
The experience of returning to work following cancer is a largely unknown area of cancer research. This preliminary study aimed to explore the factors that influence decisions about return to work eitehr during or after cancer treatment and to identify ...
Haslam, C   +8 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

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