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The kingdom of God: Utopian or existential?

HTS Teologiese Studies/Theological Studies, 2014
The kingdom of God was a central theme in Jesus’ vision. Was it meant to be understood as utopian as Mary Ann Beavis views it, or existential? In 1st century CE Palestine, kingdom of God was a political term meaning theocracy suggesting God’s patronage ...
Gert J. Malan
doaj  

“Sometimes I feel like I’m not supposed to think about death, but I do anyway” - exploring the topic of death with children in schools to help them find meaning and foster their wellbeing

Humanities & Social Sciences Communications
The quest to give a meaning to life has spanned centuries, from Plato to the existentialist philosophers and psychologists in the 20th century. Among existential questions that are quasi-universal, those around death occupy a large place.
Catherine Malboeuf-Hurtubise, David Lefrançois, Marc-André Éthier, Jonathan Smith, Kevin Péloquin, Zach Dylan Fry   +5 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

RUSSIAN VERBS OF SPATIAL ORIENTATION STAND, SIT, LIE [PDF]

, 2001
The semantics of Russian verbs of spatial orientation is far from being simple or trivial; complex spatial concepts categorized in these lexical items are based on a number of cognitive structures that emerge from different modes of man’s interaction ...
Kravchenko, Prof. A.V.
core  

Reflecting on meaning in an existential-reorientation group psychotherapy approach for cancer patients: A qualitative thematic analysis [PDF]

, 2021
Luigi Grassi, Silvana Sabato, Rosangela Caruso, Elisa Tiberto, Silvia De Padova, Federica Ruffilli, Federica Folesani, Maria Giulia Nanni, Belvederi Murri Martino, Luigi Zerbinati, Ines Testoni   +10 more
openalex   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

FACTORIAL STRUCTURE OF THE EXISTENCE SCALE [PDF]

research articleExistential meaning in life is becoming an increasingly important measure of personal assessment. In search of a suitable instrument to measure existential meaning, the authors reviewed several measures.
Brouwers, André, Tomic, Welko
core  

Attending to the Existential Experience in Oncology: Dignity and Meaning Amid Awareness of Death [PDF]

, 2022
William E. Rosa, Harvey M. Chochinov, Nessa Coyle, Rachel A. Hadler, William S. Breitbart   +4 more
openalex   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Questions and Answers about Oppositions [PDF]

, 2011
A general characterization of logical opposition is given in the present paper, where oppositions are defined by specific answers in an algebraic question-answer game. It is shown that opposition is essentially a semantic relation of truth values between
Schang, Fabien
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