Results 121 to 130 of about 1,366,823 (289)
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
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Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
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, 2013 It is often claimed that modern media massively return the repressed yet unavoidable fact of death, which modernity had institutionalised and placed out of sight.
Lagerkvist, Amanda,
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The kingdom of God: Utopian or existential?
HTS Teologiese Studies/Theological Studies, 2014 The kingdom of God was a central theme in Jesus’ vision. Was it meant to be understood as utopian as Mary Ann Beavis views it, or existential? In 1st century CE Palestine, kingdom of God was a political term meaning theocracy suggesting God’s patronage ...
Gert J. Malan
doaj
Humanities & Social Sciences CommunicationsThe quest to give a meaning to life has spanned centuries, from Plato to the existentialist philosophers and psychologists in the 20th century. Among existential questions that are quasi-universal, those around death occupy a large place.
Catherine Malboeuf-Hurtubise +5 more
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Existential meanings of education and science
Research Result Social Studies and HumanitiesRealization of educational process not just attracts to itself various human motives. Essence of education – implementation of initial existential motivation. The essence of education is the realisation of the original existential motivation. Analyses of cultural history show the existence of a basic meaning that can be called educational existential ...
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Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
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RELIGIOUS FAITH: EXISTENTIAL-ANTHROPOLOGICAL MEANINGS
Anthropological Measurements of Philosophical Research, 2019 Purpose. The aim of this article is to analyse the essential features of religious faith as an existential-personalistic model of the formation of a person, his worldview orientations and activities. This requires a consistent solution of the following tasks: a) to focus on different approaches to understanding the phenomenon of "religious faith" (as a
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ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
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Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
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