Results 101 to 110 of about 1,366,823 (289)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The practice of dealing with existential questions in long-term elderly care

International Journal of Qualitative Studies on Health & Well-Being, 2018
Purpose: Existential questions concerning life and death or meaning in life are very salient for many older people receiving long-term care. However, little is known about how long-term care organizations deal with existential issues.
Wander van der Vaart, Rosanna van Oudenaarden   +1 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Existential and embodied presence—the meaning of peer support caring as experienced by breastfeeding peer support mothers in Sweden

International Journal of Qualitative Studies on Health & Well-Being
Purpose Many mothers face breastfeeding challenges that professional healthcare lacks the capacity to address, which can evoke exposedness and vulnerability. In Sweden, the non-profit Breastfeeding Support Organisation provide breastfeeding peer support.
Lina Palmér, Tora Nord, Marita Flisbäck   +2 more
doaj   +1 more source

Modern Meaning-making [Elektronisk resurs] : Adolescent understanding of existential aspects in Health-related quality of life [HRQL]

, 2017
Aims: Present results from focus interviews concerning existential aspects related to the adaptation of the WHOQOL-SRPB(BREF) for Swedish adolescents.Background: Exploring existential aspects of HRQL are important when mental ill-health is increasing ...
Söderqvist, Fredrik,, Melder, Cecilia A,   +1 more
core  

Finding Existential Meaning After a Traumatic Brain Injury

, 2023
Meaning in life is a fundamental condition for psychological well-being and can be experienced through beliefs, values, goals, and the identities and roles one occupies.

core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Living in Limbo: Existential Concerns Among Greek Young Adults

Youth
Existential concerns are particularly salient during emerging adulthood—a period marked by identity exploration, uncertainty, and developmental transitions. This qualitative study explores the existential anxieties of Greek young adults within the unique
Dimitrios Pavlidis, Panagiota Tragantzopoulou   +1 more
doaj   +1 more source

Existential social work and the quest for existential meaning and well-being: A conceptual framework

, 2017
The aim of this article is to conceptualize “existential social work.” A greater understanding of what existential social work means may enable social workers and those studying social work to see how its practice can reveal “the truth” about human ...
Nilsson, Håkan,, Håkan Nilsson
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source