Results 81 to 90 of about 252,569 (305)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Cosmic Existentialism: Existence in an Indifferent Universe

Philosophies
The problem of meaning in an apparently indifferent universe has long been a central concern of existential philosophy. Classical existentialism addressed this question by emphasizing human freedom, responsibility, and the creation of meaning in the ...
Eduardo Duque-Dussán
doaj   +1 more source

Existential and religious motifs in L.S. Vygotsky’s essay on “Hamlet” (1916)

Культурно-историческая психология, 2018
In this article existential and religious motifs in the works of young L.S. Vygotsky are considered. The specificity of the existential approach, characterized by blurring the limits of philosophy, science and art and the formation of a synthetic method ...
Chesnokova M.G.,
doaj   +1 more source

Catalogue of Anti-Patterns for formal Ontology debugging [PDF]

, 2009
Debugging of inconsistent OWL ontologies is normally a tedious and time-consuming task where a combination of ontology engineers and domain expert is often required to understand whether the changes to be performed in order to make the OWL ontology ...
Corcho, Oscar, Roussey, C., Vilches-Blázquez, LM.   +2 more
core   +2 more sources

The Great Escape: The Role of Self-esteem and Self-related Cognition in Terror Management [PDF]

, 2015
Integrating terror management theory and objective self-awareness theory, we propose the existential escape hypothesis, which states that people with low self-esteem should be especially prone to escaping self-awareness as a distal response to thoughts
Anderson, Arnaud Wisman, Arndt, Arndt, Arndt, Asendorpf, Baldwin, Barnett, Baumeister, Becker, Blascovich, Brockner, Brown, Burke, Carver, Castano, Chatard, Cheng, Cicirelli, Davis, Davis, Dehaene, Diener, Dougherty, Du, Duval, Duval, Fazio, Fejfar, Feldman, Florian, Friedman, Goldenberg, Goldenberg, Goldenberg, Govern, Greenberg, Greenberg, Greenberg, Greenberg, Greenberg, Greenberg, Greenberg, Harlow, Harmon-Jones, Hayes, Hayes, Heatherton, Heatherton, Heine, Higgins, Hirschberger, Hull, Hull, Hull, Ickes, Jamie L. Goldenberg, Jessop, Juhl, Kesebir, Kouider, Kral, Landau, Landau, Mann, Maris, Martens, McGregor, Menard, Milgram, Mor, Moskalenko, Mullen, Muraven, Muraven, Nathan Heflick, Phillips, Pilling, Polivy, Pyszczynski, Pyszczynski, Pyszczynski, Richter, Rosenberg, Rosenblatt, Routledge, Routledge, Schimel, Schmeichel, Schmeichel, Shrout, Silvia, Silvia, Silvia, Silvia, Snow, Steele, Stein, Tafarodi, Taubman Ben-Ari, Taylor, Vaes, Vlahov, Watson, Wegner, Wegner, Wegner, Wentura, Wicklund, Wicklund, Wisman, Wisman, Wisman, Yang, Zimbardo   +114 more
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Existential concerns among young adults with psychotic vulnerability in mental health care: a qualitative study in the Netherlands

BMC Psychiatry
Background Young adults with psychotic vulnerability are dealing with disrupting experiences early in life, often with far-reaching or even lifelong impacts. These experiences can lead to existential questions during young adulthood. Identity realization
Marlous L. D. de Vries, Pauline Janse, Christa W. Anbeek, Arjan W. Braam   +3 more
doaj   +1 more source

Existential Process in Harry Potter and the Chamber of Secret: a Systemic Functional Linguistic Study [PDF]

, 2016
Dealing with sense of experience people undergo, transitivity construes the process of the experiences. One of the processes in transitivity is discussed here, that is existential process.
Afrianto, A. (Afrianto), Inayati, A. (Anisa)   +1 more
core  

Criticism, Contact With Reality and Truth [PDF]

, 1996
Partly in reply to D. Cannon’s critique of his analytical reconstruction (1988) of Polanyi’s post-critical theory of tacit knowledge, the author argues that there are good reasons for not appropriating Polanyi’s programme of self-identication and the ...
Sanders, Andy F.,
core   +3 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source