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Contemporary models of well-being remain incomplete because they overlook the existential dimension. Drawing on philosophy, phenomenology, anthropology, sociology and public health, this article proposes existential health as a fourth domain of human ...
Jim Palmer
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
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Existential and religious motifs in L.S. Vygotsky’s essay on “Hamlet” (1916)
Культурно-историческая психология, 2018 In this article existential and religious motifs in the works of young L.S. Vygotsky are considered. The specificity of the existential approach, characterized by blurring the limits of philosophy, science and art and the formation of a synthetic method ...
Chesnokova M.G.,
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
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Subject and Scripture: Exploring Existential Moments in the Ordinary Reading of Scripture
WawasanScripture reading is not only a means of extracting meaning from sacred texts, but also a way to attain certain spiritual experiences. In the Islamic tradition, reading the scriptural text, such as the holy Quran, can lead readers to certain spiritual ...
R. Yuli Ahmad Hambali
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FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
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The development of the Meaning in Life Index (MILI) and its relationship with personality and religious behaviours and beliefs among UK undergraduate students [PDF]
, 2008 The scales available for assessing meaning in life appear to be confounded with several related constructs, including purpose in life, satisfaction with life, and goal-directed behaviour.
Hills, P. R., Francis, Leslie J.
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
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Hopelessness, Presence of Meaning in Life, and Existential Concern: A Latent Profile Analysis
Psikiyatride Güncel YaklaşımlarObjective: The present study uses the variables of hopelessness, the presence of meaning in life, and existential concern to obtain a broad conceptualization of suicide risk and aims to uncover distinct latent subgroups formed by these variables. It also
Mehmet Sarıçalı, Ersoy Çarkıt
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