Results 81 to 90 of about 27,363 (307)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Russian verbs BYT’ and BYVAT’: existential and non‑existential meanings [PDF]

, 2020
Two Russian verbs with existential meaning are compared – byt’ and byvat’. The verb byt’ “to be” is the main existential verb in Russian: collocations existential sentences and existential verbs are translated into Russian as bytijnye predloženia “existential sentences” and bytijnye glagoly “existential verbs.” The verb byt’ is ambiguous.
openaire   +1 more source

On the structure and meaning of NPs in Turkish existentials

, 2022
This paper analyzes the structural and interpretive properties of Noun Phrases (NPs henceforth) in Turkish existential sentences. There are three different types of NPs, namely bare NPs, singular indefinite NPs and plural indefinite NPs, that can appear in existential structures.
Görgülü, Emrah, Görgülü, Emrah
openaire   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

ATTITUDE OF EXISTENTIALISM ABOUT "EXISTENTIAL DYING" AND ITS HUMANISTIC MEANING

Hue University Journal of Science: Social Sciences and Humanities, 2019
Existentialism is the philosophy of attitudes, a step away from traditional philosophy. The stance of existentialism of "dying" is one of those attitudes. Dying is a process by which the subject loses subjectivity, leading to a loss of personality due to the disparity between material life and the spiritual life that people do not recognize.
Nguyễn Tiến Dũng, Phạm Thị Thúy Sương   +1 more
openaire   +2 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

New Memory Cultures and Death [Elektronisk resurs] : Existential Security in the Digital memory Ecology

, 2013
It is often claimed that modern media massively return the repressed yet unavoidable fact of death, which modernity had institutionalised and placed out of sight.
Lagerkvist, Amanda,
core   +1 more source

Existential Sentences Crosslinguistically: Variations in Form and Meaning [PDF]

Annual Review of Linguistics, 2016
Though the term “existential sentence” goes back at least as far as Jespersen (1924 , p. 155) and is used in descriptions of many languages to refer to a designated construction, it is difficult to identify exactly what these constructions have in common crosslinguistically. Following McNally (2011 , p. 1829), the term is used here to refer to sentence
openaire   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Hopelessness, Presence of Meaning in Life, and Existential Concern: A Latent Profile Analysis

Psikiyatride Güncel Yaklaşımlar
Objective: The present study uses the variables of hopelessness, the presence of meaning in life, and existential concern to obtain a broad conceptualization of suicide risk and aims to uncover distinct latent subgroups formed by these variables. It also
Mehmet Sarıçalı, Ersoy Çarkıt
doaj   +1 more source