Results 91 to 100 of about 252,569 (305)

Jaspers, Husserl, Kant: boundary situations as a " turning point" [PDF]

, 2017
: The essay addresses the meaning of boundary situations in the philosophy of Karl Jaspers, as a turning point drawing on Edmund Husserl's phenomenology and Immanuel Kant's transcendental philosophy, and as a key for the comprehension
Portuondo, Gladys L.
core  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Some Concerns Regarding Ternary-relation Semantics and Truth-theoretic Semantics in General [PDF]

, 2017
This paper deals with a collection of concerns that, over a period of time, led the author away from the Routley–Meyer semantics, and towards proof- theoretic approaches to relevant logics, and indeed to the weak relevant logic MC of meaning ...
Brady, Ross T.
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hopelessness, Presence of Meaning in Life, and Existential Concern: A Latent Profile Analysis

Psikiyatride Güncel Yaklaşımlar
Objective: The present study uses the variables of hopelessness, the presence of meaning in life, and existential concern to obtain a broad conceptualization of suicide risk and aims to uncover distinct latent subgroups formed by these variables. It also
Mehmet Sarıçalı, Ersoy Çarkıt
doaj   +1 more source

Bergman’s Cinema in the mirror of Existential Philosophies [PDF]

حکمت و فلسفه
This paper presents analysis of the cinema of Ingmar Bergman through the lens of existential philosophies. Bergman, recognized as one of the Prominent and Influential Filmmakers of the 20th century, masterfully uses the language of cinema to explore the ...
Ali Arbabi, Mohammad Raayat Jahromi
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Existential boredom as a phenomenon of human social existence

Sovremennye Issledovaniâ Socialʹnyh Problem
Background. Until now, science lacks a holistic philosophical understanding of the phenomenon of existential boredom and has not developed an attitude towards it, although it is recognized in the scientific community.
Svetlana M. Maltseva, Polina O. Ivanova, Olga P. Kashina   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The Existential Vacuum and Its Relationship to Pessimism and Optimism among Undergraduate Students

Islamic Guidance and Counseling Journal
University students may confront an existential vacuum, characterized by a loss of life's meaning resulting from personal crises, socio-political shifts, and health transformations. These challenges, which some young individuals may struggle to adapt to,
Mohammed H. Abood, Thaer A. Ghbari
doaj   +1 more source