Results 111 to 120 of about 252,569 (305)

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

open access: yesMolecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor   +2 more
wiley   +1 more source

From Yeezus to Pablo: An Existential Theology between God, Blackness, and Being [PDF]

open access: yes, 2018
Kanye West has transformed and transfigured from a young rapper representing the Southside of Chicago, to an icon, a rap genius, a god. His persona has continually evolved from his arrival on the Hip Hop scene, leading to his emergence as, Yeezus. This
Watts, Shea
core   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

open access: yesFEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz   +9 more
wiley   +1 more source

Existential Antropology as the Antropology of Education

open access: yesДискурс Пи, 2018
The article reveals author's version of the concept of existential anthropology education, where axiological component is strengthened as the basis for education of human being.
N.N. Niyazbaeva
doaj   +1 more source

Preaching to Episodic Ears: Practicing a Dramaturgical Homiletic

open access: yes, 2019
This article is a critical attempt to develop a homiletic methodology for preaching to the episodic self of the 21st century. The British philosopher Galen Strawson contends that postmodern people today do not regard themselves as living out their lives ...
Yang, Sunggu
core  

On Love and Awareness [PDF]

open access: yes, 1994
In this paper, I will discuss some aspects of a humanistic perspective on love which includes both idealistic as well as realistic elements of love.
Wautischer, Helmut
core  

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

open access: yesFEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen   +6 more
wiley   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

open access: yesFEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand   +2 more
wiley   +1 more source

The Protective Role of Curiosity Behaviors in Coping with Existential Vacuum

open access: yesBehavioral Sciences
An existential vacuum is experienced as a kind of crisis that one can cope with using his/her strengths. The related literature suggests that the important determinants of coping with existential emptiness include positive emotional and personality ...
Barbara Gawda, Adrian Korniluk
doaj   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

open access: yesFEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti   +3 more
wiley   +1 more source

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