Results 81 to 90 of about 518,991 (261)

THE MEANING OF LIFE WAYANG WONG SRIWEDARI PLAYERS

Jurnal Empati, 2015
The meaning of life is something that is considered important, valuable, and desirable as well as provide special value to one's self. The meaning of life is also worthy life goals. This study aims to find a vision of the meaning of life from the players
Gilang Rastu Gati, Zaenal Abidin
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Relationships Matter Most: A Mixed Methods Study into Meaning in Life in Personality Disorder, Before and After Treatment

Religions
Meaning in life is often at stake in patients with personality disorder (PD) and associated with a lack of self-direction. Meaning in life, including religion and spirituality, seems to contain facets within personality and facets independent of ...
Angelien Steen, Pauline Sam, Carmen Schuhmann, Arjan W. Braam   +3 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Meaning in Life as a Moderator of the Association Between Future Anxiety and Depression

Jurnal Psikologi
This study examines meaning in life as a moderator of the association between future anxiety and depression in 251 final-year university students in Yogyakarta, Indonesia (aged 18-25). Finishing university, a key time in young adulthood, can be stressful
Farrell Adhitama, Lavenda Geshica
doaj   +1 more source

Makna Hidup pada Wanita Dewasa yang Terlambat Menikah

Jurnal Diversita, 2018
This research was a qualitative research regarding the meaning of life for unmarried woman. There are four components that were explored, the causes and psychological effect they experienced, coping strategy that used and the meaning of life that was ...
Maqhfirah DR
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source