Results 161 to 170 of about 166,958,153 (304)

Meaning of Work-life Balance for Workers With Disabilities. [PDF]

Saf Health Work
Kim J.
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Control, identity and meaning in voluntary work : the case of the Royal National Lifeboat Institution [PDF]

Organization studies, including studies of control and identity, has to date been almost exclusively concerned with organizations where work is paid for. By contrast, this thesis considers the dynamics of control and identity when work is unpaid, through
O'Toole, Michelle
core  

What is life worth living for? A systematic review on meaning in life and meaning in work as protective factors for healthcare professionals' wellbeing. [PDF]

Health Psychol Rep
Corbella G, Pierobon A, Maffoni M.
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Why management studies need the organizational ethnographer [PDF]

, 2005
van Marrewijk, A., Verweel, P., LSG Management of Meaning (MOM), Management of Meaning, Universiteit Utrecht, Vermeulen, J., van Slobbe, N.   +6 more
core  

The meaning of work for hospital unit nurses: a scoping review. [PDF]

Rev Bras Med Trab
Caroccini TP, Balsanelli AP, Neves V.
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Baken op nieuwe reis of rondje om de kerk? De beleidstekst van een christelijke hogeschool als culturele praktijk [PDF]

, 2004
LSG Management of Meaning (MOM), Management of Meaning, Universiteit Utrecht, Vermeulen, J.   +3 more
core