Results 181 to 190 of about 166,958,153 (304)

Engagement, Passion and Meaning of Work as Modulating Variables in Nursing: A Theoretical Analysis. [PDF]

Int J Environ Res Public Health, 2019
Gómez-Salgado J, Navarro-Abal Y, López-López MJ, Romero-Martín M, Climent-Rodríguez JA.   +4 more
europepmc   +1 more source

Work and Non-Work. On Work and Meaning

, 2020
I den politiska retoriken florerar debattinlägg om arbetslivet, och målsättningen är för det mesta att så många som möjligt ska arbeta så länge som möjligt. Att skapa jobb och minimera arbetslösheten ses som de främsta utmaningarna. På ett individuellt plan beskrivs arbete ofta som personligt självförverkligande eller som en nödvändig form av inkomst ...
openaire   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

"Back to Bedside": Residents' and Fellows' Perspectives on Finding Meaning in Work. [PDF]

J Grad Med Educ, 2017
Hipp DM, Rialon KL, Nevel K, Kothari AN, Jardine LDA.   +4 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

De Tweede loopgolf. Over groei en omvang van de loopsportmarkt en hoe de KNAU haar marktaandeel verder kan vergroten [PDF]

, 2006
LSG Management of Meaning (MOM), van Bottenburg, M., Management of Meaning   +2 more
core  

A Threshold of Meaning for Work Disability Improvement in Psoriatic Arthritis Measured by the Work Productivity and Activity Impairment Questionnaire. [PDF]

Rheumatol Ther, 2019
Tillett W, Lin CY, Zbrozek A, Sprabery AT, Birt J.   +4 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

International survey responses from an interdisciplinary cohort of spinal cord injury clinicians assessing professional burnout and meaning in work. [PDF]

Spinal Cord Ser Cases, 2019
Slocum C, Stillman M, Capron M, Alexander S, Hultling C.   +4 more
europepmc   +1 more source