Results 91 to 100 of about 709,129 (333)

Sense-Making, Meaningfulness, and Instrumental Music Education [PDF]

, 2020
The purpose of this paper is to re-examine the nature of “meaning” and “meaningfulness” in the context of instrumental music education. By doing so, I propose to expand the ways in which instrumental music educators conceive their mission and the ways in
Marissa Silverman, Silverman, Marissa
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Meaning of work for South African women during the pandemic

SA Journal of Human Resource Management
Orientation: The coronavirus disease 2019 (COVID-19) pandemic disrupted workplaces worldwide, prompting a re-evaluation of the meaning and significance of work, particularly among women who were uniquely impacted by the crisis.
Ashley C. Jacobs, Nelesh Dhanpat, Neo Mamathuba   +2 more
doaj   +1 more source

Meaningfulness of Work and Employee Engagement: The Role of Affective Commitment

Open Psychology Journal, 2020
Meaningfulness of work leads to positive job-related consequences, such as engaged, satisfied, productive, trustworthy, and devoted employees.The main purpose of this research was to study the relationship between meaningfulness of work, employee ...
Prabhjot Kaur, Amit Mittal
semanticscholar   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

The algorithm of questionnaire data analysis in sports and pedagogical researches [PDF]

Pedagogìka, Psihologìâ ta Mediko-bìologìčnì Problemi Fìzičnogo Vihovannâ ì Sportu, 2012
Questions with the use of methods of mathematical statistics in sporting pedagogical practice are considered. The necessity of opening of maintenance and methods of unnumerical statistics is well-proven in the process of treatment of these researches of ...
Denisova L.V., Usychenko V.V., Byshevets N.G.   +2 more
doaj  

Usable environmental knowledge from the perspective of decision-making: the logics of consequentiality, appropriateness, and meaningfulness

, 2020
Environmental knowledge is a crucial input for public and private decision-making, yet often useful environmental knowledge appears to be unusable for decision-makers.
A. Dewulf, Nicole L. Klenk, C. Wyborn, M. Lemos   +3 more
semanticscholar   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source