Results 91 to 100 of about 674,697 (350)

Comparison of Effective and Non-Effective Icons in the Searching Module Concerning Familiarity and Meaningfulness in Azarakhsh, Simorgh and Nika Digital Libraries [PDF]

کتابداری و اطلاع‌رسانی, 2016
Purpose: The present study aimed to compare effective and non-effective icons in the searching module with regard to familiarity and meaningfulness in Azarakhsh, Simorgh and Nika digital libraries.
Mahdieh Mirzabegi, Sanaz Rahrovani, Javade Abbaspur   +2 more
doaj  

Usable environmental knowledge from the perspective of decision-making: the logics of consequentiality, appropriateness, and meaningfulness

, 2020
Environmental knowledge is a crucial input for public and private decision-making, yet often useful environmental knowledge appears to be unusable for decision-makers.
A. Dewulf, Nicole L. Klenk, C. Wyborn, M. Lemos   +3 more
semanticscholar   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Understanding meaningfulness in videogames [PDF]

, 2008
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Comparative Media Studies, February 2008.Includes bibliographical references (p. 76-80).This thesis explores "meaningfulness" in videogames. Academics, journalists, and others who write about
Weise, Matthew Jason
core  

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Meaning of work for South African women during the pandemic

SA Journal of Human Resource Management
Orientation: The coronavirus disease 2019 (COVID-19) pandemic disrupted workplaces worldwide, prompting a re-evaluation of the meaning and significance of work, particularly among women who were uniquely impacted by the crisis.
Ashley C. Jacobs, Nelesh Dhanpat, Neo Mamathuba   +2 more
doaj   +1 more source

Measurement and meaningfulness

ACTA IMEKO, 2014
<p>This is a reissue of a paper which appeared in ACTA IMEKO 1985, Proceedings of the 10th World Congress of the International Measurement Confederation, "New measurement technology to serve mankind", 22.-26.4.1985, Prague, pp. 319-333.</p><p>The question raised in this paper is: What is the meaning of a statement in which reference ...
openaire   +3 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Meaningfulness and Time [PDF]

, 2011
(Pdf updated to final, slightly revised version of November 2010) Almost everyone would prefer to lead a meaningful life. But what is meaning in life and what makes a life meaningful? I argue, first, for a new analysis of the concept
Kauppinen, Antti
core