Results 71 to 80 of about 674,697 (350)

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

EEG Differentiation Analysis and Stimulus Set Meaningfulness

Frontiers in Psychology, 2017
A set of images can be considered as meaningfully different for an observer if they can be distinguished phenomenally from one another. Each phenomenal difference must be supported by some neurophysiological differences.
Armand Mensen, Armand Mensen, William Marshall, Giulio Tononi   +3 more
doaj   +1 more source

The relationship between new product creativity components and purchase intention and the mediating impact of perceived values: a study of consumers in Ho Chi Minh city

Cogent Business & Management, 2022
This study aims to extend creativity literature based on consumers’ perspective by examining empirically the effects of new product creativity dimensions of novelty and meaningfulness on consumers’ purchase intention with the mediating roles of perceived
Tho Phuoc Vo, Mai Dong Tran, Thi Minh Chau Ly   +2 more
doaj   +1 more source

Finding order within the disorder: a case study exploring the meaningfulness of delusions

BJPsych Bulletin, 2021
Can delusions, in the context of psychosis, enhance a person’s sense of meaningfulness? The case described here suggests that, in some circumstances, they can.
R. Ritunnano, Clara S. Humpston, M. Broome   +2 more
semanticscholar   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Callings and work engagement: Moderated mediation model of work meaningfulness, occupational identity, and occupational self-efficacy [PDF]

, 2012
Scholarly interest in callings is growing, but our understanding of how and when callings relate to career outcomes is incomplete. The present study investigated the possibility that the relationship of calling to work engagement is mediated by work ...
Hirschi, Andreas
core   +1 more source

Uncovering metacognitive awareness and meaningful learning of prospective mathematics teachers after learning absolute value inequalities

Journal of Research and Advances in Mathematics Education
Learners who lack adequate metacognitive awareness and meaningful have the potential to work mechanically. The aims of this study is to uncover the characteristics and description of metacognitive awareness and meaningful of prospective mathematics ...
Wayan Rumite, Halil Arianto, Syamsinar Syamsinar   +2 more
doaj   +1 more source

Paradoxical experiences of healthcare workers during COVID-19: a qualitative analysis of anonymous, web-based, audio narratives

International Journal of Qualitative Studies on Health & Well-Being, 2023
Purpose To gain a deeper understanding of healthcare workers experiences during COVID-19 using an anonymous, web-based, audio narrative platform. Methods Data were collected from healthcare workers in the midwestern United States using a web-enabled ...
Lori Lackman Zeman, Sujoy Roy, Pranjali P. Surnis, Jason Adam Wasserman, Kathleen Duchak, Ramin Homayouni, Elie Mulhem   +6 more
doaj   +1 more source

Effects of mentoring on work engagement: Work meaningfulness as a mediator

International Journal of Training and Development, 2021
This study examined the relationship between career mentoring and work engagement from the mentor perspective, by estimating work meaningfulness as a mediator.
Ligui Lin, Xuejing Cai, Jun Yin
semanticscholar   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source