Results 101 to 110 of about 738,687 (339)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

The algorithm of questionnaire data analysis in sports and pedagogical researches [PDF]

open access: yesPedagogìka, Psihologìâ ta Mediko-bìologìčnì Problemi Fìzičnogo Vihovannâ ì Sportu, 2012
Questions with the use of methods of mathematical statistics in sporting pedagogical practice are considered. The necessity of opening of maintenance and methods of unnumerical statistics is well-proven in the process of treatment of these researches of ...
Denisova L.V.   +2 more
doaj  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

Applying Agenda-Setting Theory to Consumer Products: Oregon Wine [PDF]

open access: yes, 2010
This project examines how Oregon winemakers present themselves to the media and their consumers, and whether or not their portrayal is received correctly by these sources. This research focuses mainly on what message producers convey to the media and how
Paysinger, Katie, Weidman, Lisa
core   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

open access: yesMolecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Response probability and latency: a straight line, an operational definition of meaning and the structure of short term memory [PDF]

open access: yes, 2007
The functional relationship between response probability and time is investigated in data from Rubin, Hinton and Wenzel (1999) and Anderson (1981). Recall/recognition probabilities and search times are linearly related through stimulus presentation lags
Tarnow, Dr. Eugen
core  

The Implications of Interactions for Science and Philosophy

open access: yes, 2011
Reductionism has dominated science and philosophy for centuries. Complexity has recently shown that interactions---which reductionism neglects---are relevant for understanding phenomena.
A. Toffler   +9 more
core   +1 more source

Meaningfulness, the unsaid and translatability. Instead of an introduction [PDF]

open access: yes, 2015
The present paper opens this topical issue on translation techniques by drawing a theoretical basis for the discussion of translational issues in a linguistic perspective.
Keidan, Artemij
core   +3 more sources

Warren J. Samuels (1933-2011) [PDF]

open access: yes, 2012
This paper examines the research and career of the late Warren J. Samuels (1933-2011), an influential institutionalist economist in the Wisconsin John Commons tradition and well-known historian and methodologist of economics.
Davis, John B.
core   +1 more source

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