Results 61 to 70 of about 3,609,059 (246)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

A fault state detection method for DC charging pile charging module based on minimum fourth-order moments adaptive filtering algorithm

Journal of Radiation Research and Applied Sciences
It is necessary to accurately judge the fault state of the charging module of DC charging pile in order to ensure the safe and reliable operation of DC charging pile.
Yongmin Zhang, Jihua Bao, Jingjing Li, Yongmei Cai, Wenjin Yu, Yinshan Guo, Feng Xu   +6 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

First quarter quality assurance report for True Geothermal Energy Company Monitoring Program, Kilauea Middle East Rift Zone, island of Hawaii : November 1, 1989 - January 31, 1990 [PDF]

, 1990
"The aerometric analyzer audit results were satisfactory. The sulfur dioxide (502) and hydrogen sulfide (H2S) analyzers meet the slope and intercept criteria.
Measurement Technologies
core   +2 more sources

Towards Industry 5.0: Emerging trends in dual-arm human–robot collaboration

Biomimetic Intelligence and Robotics
As industry transitions from the Industry 4.0 paradigm to the human-centered vision of Industry 5.0, robots are evolving from mere automation tools into intelligent partners capable of close collaboration with humans.
Jinhua Ye, Yechen Fan, Gengfeng Zheng, Houde Dai, Chenyang Song, Haibin Wu, Yu Zhang   +6 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Avaliação da acurácia do rastreômetro: um novo equipamento para rastreamento de hipertensão arterial Evaluation of accuracy of rastreometer: a new equipment for hypertension tracking

Arquivos Brasileiros de Cardiologia, 2012
Fundamento: A hipertensão arterial sistêmica é um dos principais fatores de risco cardiovascular afetando mais de um bilhão de pessoas. A baixa taxa de conhecimento da doença constitui uma das maiores dificuldades relacionadas à hipertensão.
Fernando Bitencourt, Carlos Antonio Mascia Gottschall   +1 more
doaj  

A Soft Sensor Modeling Method Based on Local Migration Modeling Framework

Sensors
To address the issues of low model fitting accuracy and insufficient prediction capability caused by the multi-stage characteristics and batch-to-batch data distribution heterogeneity in the fermentation process of Pichia pastoris, this study proposed a ...
Bo Wang, Shaowen Huang, Hangfei Cai
doaj   +1 more source