Results 81 to 90 of about 390,592 (304)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Performance Complexity Measurement of Tightening Equipment Based on Kolmogorov Entropy [PDF]

, 2017
The performance of the tightening equipment will decline with the working process in manufacturing system. The main manifestations are the randomness and discretization degree increasing of the tightening performance. To evaluate the degradation tendency
Xuemei Liu, Guoliang Fan, Aiping Li, Liyun Xu   +3 more
core   +1 more source

Avaliação da acurácia do rastreômetro: um novo equipamento para rastreamento de hipertensão arterial Evaluation of accuracy of rastreometer: a new equipment for hypertension tracking

Arquivos Brasileiros de Cardiologia, 2012
Fundamento: A hipertensão arterial sistêmica é um dos principais fatores de risco cardiovascular afetando mais de um bilhão de pessoas. A baixa taxa de conhecimento da doença constitui uma das maiores dificuldades relacionadas à hipertensão.
Fernando Bitencourt, Carlos Antonio Mascia Gottschall   +1 more
doaj  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Precisão do aparelho Omron HEM-705 CP na medida de pressão arterial em grandes estudos epidemiológicos Precisión del aparato Omron HEM-705 CP en la medida de presión arterial en grandes estudios epidemiológicos Accuracy of the Omron HEM-705 CP for blood pressure measurement in large epidemiologic studies

Arquivos Brasileiros de Cardiologia, 2011
FUNDAMENTO: A medida precisa da pressão arterial (PA) é de grande importância na pesquisa da hipertensão. No contexto de estudos clínicos e epidemiológicos, dispositivos oscilométricos frequentemente oferecem importantes vantagens para superar algumas ...
Lina M. Vera-Cala, Myriam Orostegui, Laura I. Valencia-Angel, Nahyr López, Leonelo E. Bautista   +4 more
doaj  

Towards Industry 5.0: Emerging trends in dual-arm human–robot collaboration

Biomimetic Intelligence and Robotics
As industry transitions from the Industry 4.0 paradigm to the human-centered vision of Industry 5.0, robots are evolving from mere automation tools into intelligent partners capable of close collaboration with humans.
Jinhua Ye, Yechen Fan, Gengfeng Zheng, Houde Dai, Chenyang Song, Haibin Wu, Yu Zhang   +6 more
doaj   +1 more source

Fruit recognition based on pulse coupled neural network and genetic Elman algorithm application in apple harvesting robot

International Journal of Advanced Robotic Systems, 2020
In order to improve the harvesting efficiency of apple harvesting robot, this article presents an apple recognition method based on pulse coupled neural network and genetic Elman neural network (GA-Elman).
Weikuan Jia, Shanhao Mou, Jing Wang, Xiaoyang Liu, Yuanjie Zheng, Jian Lian, Dean Zhao   +6 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

A Soft Sensor Modeling Method Based on Local Migration Modeling Framework

Sensors
To address the issues of low model fitting accuracy and insufficient prediction capability caused by the multi-stage characteristics and batch-to-batch data distribution heterogeneity in the fermentation process of Pichia pastoris, this study proposed a ...
Bo Wang, Shaowen Huang, Hangfei Cai
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source