Results 111 to 120 of about 5,839,450 (292)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

VNA Tools—A Metrology Software Supporting the Digital Traceability Chain

Metrology
This paper presents METAS VNA Tools Version 2.9.0, a metrology software suite designed to support the digital traceability chain in vector network analyzer measurements.
Markus Zeier, Michael Wollensack, Johannes Hoffmann, Peter Morrissey, Juerg Ruefenacht, Daniel Stalder   +5 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Model for Measuring Urban Development with a Socioeconomic Focus in Lima, Medellin and San Salvador

Urban Science
The measurement of urban development in Latin American cities has historically relied on one-dimensional models focused on GDP or density, which are insufficient to guide policies in heterogeneous and unequal contexts.
Fray L. Becerra-Suarez, Carlos M. Carcache Rivas, Mónica Díaz, Juan Camilo Mesa Bedoya   +3 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Open-loop mode resonance risk determination based on measurement model

电力工程技术
The open-loop mode resonance theory is an important theoretical achievement to explain the mechanism of system instability caused by the grid connection of permanent magnet synchronous generator (PMSG), but the determination of the resonance risk of open-
Xingliang ZHANG, Wenjuan DU, Haifeng WANG   +2 more
doaj   +1 more source

Teacher Engagement as a Multidimensional Construct: Insights From a Measurement Model Analysis

Jurnal Kependidikan
This study aims to evaluate teacher engagement as a multidimensional, reflective construct comprising four dimensions: academic support, emotional support, guidance support, and assessment support.
Nurkhairo Hidayati, Leni Armayati, Ummi Kalsum, Iffa Ichwani Putri   +3 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Medical practitioner compassion: Development and validation of a compassion competency questionnaire

African Journal of Psychological Assessment
There is a need for a psychometrically robust questionnaire measuring medical practitioner compassion in healthcare. Without such a measure, competence on this construct cannot be assessed, nor can the effectiveness of interventions designed to enhance ...
Michelle Jäckel-Visser, Carl C. Theron, Robert J. Mash   +2 more
doaj   +1 more source