Results 91 to 100 of about 1,342,843 (277)

Effectiveness of a Parent Training Intervention for Children with Comorbid Autism Spectrum Disorder and Behavioral Problems in Alexandria, Egypt

Journal of High Institute of Public Health
Background: Parents of children with autism spectrum disorder (ASD) experience several negative psychological outcomes that are compounded by the presence of children’s comorbid behavioral problems.
Sally S. Othman, Mervat W. Abu‑Nazel, Tarek E.I. Omar, Heba A. Abdelaziz, Zeinab N. Shata   +4 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A psychological talking therapy for suicidality in people experiencing non-affective psychosis: Mechanism and efficacy outcomes of the CARMS (Cognitive AppRoaches to coMbatting Suicidality) randomised controlled trial

Efficacy and Mechanism Evaluation
Background Suicide is a leading cause of death worldwide, particularly in people with severe mental health problems, including schizophrenia. The development, and testing, of suicide-focused psychological interventions which can combat suicidal ...
Patricia Gooding, Yvonne Awenat, Richard Drake, Richard Emsley, Steven Jones, Navneet Kapur, Fiona Lobban, Sarah Peters, Daniel Pratt, Rachel Elliott, Bradley Boardman, Elizabeth Camacho, Danielle Edwards, Kamelia Harris, Charlotte Huggett, Gillian Haddock   +15 more
doaj   +1 more source

Obesogenic Environmental Influences on Young Adults: Evidence From Randomized Dormitory Assignment [PDF]

, 2014
This study utilizes a natural experiment—conditionally random dormitory assignments of first-year US college students—to investigate the influence of obesogenic environmental factors in explaining changes in weight and exercise behavior during the 2009 ...
Eisenberg, Daniel, Kapinos, Kandice A, Yakusheva, Olga   +2 more
core   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Clinical outcomes and adverse events of bariatric surgery in adults with severe obesity in Scotland: the SCOTS observational cohort study

Health Technology Assessment
Background Bariatric surgery is a common procedure worldwide for the treatment of severe obesity and associated comorbid conditions but there is a lack of evidence as to medium-term safety and effectiveness outcomes in a United Kingdom setting. Objective
Ruth M Mackenzie, Abdulmajid Ali, Duff Bruce, Julie Bruce, Ian Ford, Nicola Greenlaw, Eleanor Grieve, Mike Lean, Robert S Lindsay, Joanne O’Donnell, Naveed Sattar, Sally Stewart, Jennifer Logue   +12 more
doaj   +1 more source

Basic skills, soft skills and labour market outcomes : secondary analysis of the national child development study [PDF]

http://ioe.sirsidynix.net.uk/uhtbin/cgisirsi/x/0/0/57/5/3?searchdata1=197738{CKEY}&searchfield1=GENERAL^SUBJECT^GENERAL^^&user_id ...
Machin, Stephen, Vignoles, Anna, Viitanen, Tarja   +2 more
core  

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Measurements of Nondegenerate Discrete Observables

, 2000
Every measurement on a quantum system causes a state change from the system state just before the measurement to the system state just after the measurement conditional upon the outcome of measurement.
Ozawa, Masanao
core   +2 more sources