Results 31 to 40 of about 14,586,980 (256)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Reading the International Fruit Company Saga More than 50 Years Later: At the Intersection of the ‘Common’ Market, Agricultural Policy and Commercial policy

European Papers
(Series Information) European Papers - A Journal on Law and Integration, 2026 11(1), 171-193 | Article | (Table of Contents) 1. Introduction. – 2. The legal and historical context of the International Fruit Company saga at the Community and international
Silvia Giudici
doaj   +1 more source

How to Save You Skin When Processing L2 Idioms: An Eye Movement Analysis of Idiom Transparency and Cross-language Similarity among Bilinguals [PDF]

Iranian Journal of Language Teaching Research, 2017
The current study looks at whether bilinguals varying in language dominance show a processing advantage for idiomatic over non-idiomatic phrases and to what extent this effect is modulated by idiom transparency (i.e., the degree to which the idiom’s ...
Anna Cieślicka, Roberto R. Heredia
doaj  

What matters most to patients following percutaneous coronary interventions? A new patient-reported outcome measure developed using Rasch analysis.

PLoS ONE, 2019
IntroductionMeasuring patient reported outcomes can improve the quality and effectiveness of healthcare interventions. The aim of this study was to identify the final set of items that can be included in a patient-reported outcome measure to assess ...
Sze-Ee Soh, Anna L Barker, Darshini R Ayton, Susannah Ahern, Renata Morello, Jeffrey Lefkovits, Angela L Brennan, Susan Evans, John R Zalcberg, Christopher M Reid, John J McNeil   +10 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Neighbourhood socioeconomic inequalities in incidence of acute myocardial infarction: a cohort study quantifying age- and gender-specific differences in relative and absolute terms

BMC Public Health, 2012
Background Socioeconomic status has a profound effect on the risk of having a first acute myocardial infarction (AMI). Information on socioeconomic inequalities in AMI incidence across age- gender-groups is lacking.
Koopman Carla, van Oeffelen Aloysia AM, Bots Michiel L, Engelfriet Peter M, Verschuren WM, van Rossem Lenie, van Dis Ineke, Capewell Simon, Vaartjes Ilonca   +8 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Measuring and decomposing inequity in self-reported morbidity and self-assessed health in Thailand

International Journal for Equity in Health, 2007
Background In recent years, interest in the study of inequalities in health has not stopped at quantifying their magnitude; explaining the sources of inequalities has also become of great importance. This paper measures socioeconomic inequalities in self-
Sidorenko Alexandra, Carmichael Gordon A, Lim Lynette LY, Yiengprugsawan Vasoontara, Sleigh Adrian C   +4 more
doaj   +1 more source