Results 101 to 110 of about 361,322 (325)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Comparing Security Notions of Secret Sharing Schemes

Entropy, 2015
Different security notions of secret sharing schemes have been proposed by different information measures. Entropies, such as Shannon entropy and min entropy, are frequently used in the setting security notions for secret sharing schemes.
Songsong Dai, Donghui Guo
doaj   +1 more source

Structural Information in Two-Dimensional Patterns: Entropy Convergence and Excess Entropy

, 2002
We develop information-theoretic measures of spatial structure and pattern in more than one dimension. As is well known, the entropy density of a two-dimensional configuration can be efficiently and accurately estimated via a converging sequence of ...
A. Lempel, A.G. Schlijper, A.G. Schlijper, A.G. Schlijper, A.N. Pavlov, B. Baumgartner, C. Andraud, C. Andraud, C.D.Van Siclen, D. Arnold, D. Sheinwald, D.P. Feldman, D.P. Varn, David P. Feldman, E. Olbrich, E. Soljanin, E.M. Sal’nikova, H. Meirovitch, H. Meirovitch, H. Meirovitch, H. Meirovitch, H. Meirovitch, J.D. Farmer, J.L. McCauley, J.P. Crutchfield, J.P. Crutchfield, J.P. Crutchfield, J.P. Crutchfield, J.P. Crutchfield, James P. Crutchfield, K. Lindgren, K. Lindgren, K. Young, P. Grassberger, P.-M. Binder, R. Piasecki, R. Piasecki, R. Piasecki, R.L.C. Vink, S. Goldstein, S. Marcelja, T. Schürmann, V. Spirin, V. Spirin, W. Bialek, W. Ebeling, W. Li, Y.A. Andrienko, Z. Alexandrowicz, Z. Alexandrowicz   +49 more
core   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Time Resolution Dependence of Information Measures for Spiking Neurons: Atoms, Scaling, and Universality

, 2015
The mutual information between stimulus and spike-train response is commonly used to monitor neural coding efficiency, but neuronal computation broadly conceived requires more refined and targeted information measures of input-output joint processes.
Crutchfield, James P., DeWeese, Michael R., Marzen, Sarah E.   +2 more
core  

An Information-Theoretic Foundation for the Weighted Updating Model

, 2016
Weighted Updating generalizes Bayesian updating, allowing for biased beliefs by weighting the likelihood function and prior distribution with positive real exponents.
Zinn, Jesse Aaron
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

The distribution of information for sEMG signals in the rectal cancer treatment process

, 2018
The electrical activity of external anal sphincter can be registered with surface electromyography. This signals are known to be highly complex and nonlinear.
Machura, Lukasz, Nowakowski, Michal, Salowka, Jerzy, Trybek, Paulina   +3 more
core   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source