Advanced Science, EarlyView.This study reveals that photothermal therapy, while inducing immunogenic cell death in triple‐negative breast cancer, paradoxically activates the oncogenic mTOR pathway to drive immune evasion. To counter this, a smart nanocomposite is engineered to co‐deliver localized hyperthermia and mTOR inhibition.
Yujie Zhao +13 more
wiley +1 more source
Advanced Science, EarlyView.By integrating biomechanical and epigenetic cues, the evolutionarily conserved TPM1 super‐enhancer drives myogenesis via TEAD4‐mediated chromatin looping. This mechanism produces species‐specific outputs (linear TPM1 mRNA in mice and CircTPM1 in bovine) that activate PI3K/AKT mechanotransduction and the MYH10/MYL3 axis to execute cytoskeletal ...
Ruimen Zhang +27 more
wiley +1 more source
A Trypsin‐Like Serine Protease ZmNAL1a Fine‐Tunes Maize Floral Transition and Flowering Time
Advanced Science, EarlyView.This study identifies a trypsin‐like serine protease, ZmNAL1a, that moves from leaves to the shoot apical meristem. ZmNAL1a promotes the floral transition by degrading TOPLESS‐like corepressor REL2, which thereby enhances the expression of key flowering genes through elevating histone acetylation and relieving REL2–ZmEREBP147‐mediated transcriptional ...
Nan Li +15 more
wiley +1 more source
Development of meat analog patty using lion’s mane mushroom and pumpkin seeds [PDF]
Marco Marcello, Yuniwaty Halim
openalex +1 more source
A Novel Approach for Tuning the Physicochemical, Textural, and Sensory Characteristics of Plant-Based Meat Analogs with Different Levels of Methylcellulose Concentration [PDF]
, 2021 Allah Bakhsh +5 more
openalex +1 more source
Mechanism‐Driven Screening of Membrane‐Targeting and Pore‐Forming Antimicrobial Peptides
Advanced Science, EarlyView.To combat antibiotic resistance, this study employs mechanism‐driven screening with machine learning to identify pore‐forming antimicrobial peptides from amphibian and human metaproteomes. Seven peptides are validated, showing minimal toxicity and membrane disruption.
Jiaxuan Li +9 more
wiley +1 more source
Production of Vitamin D3-Fortified Plant-Based Meat Analogs Through High-Moisture Extrusion [PDF]
Lorena Silva Pinho +5 more
openalex +1 more source
Accurate Identification of Protein Binding Sites for All Drug Modalities Using ALLSites
Advanced Science, EarlyView.ALLSites is a unified sequence‐based framework for identifying proteome‐wide binding sites across all drug modalities. It integrates a gated convolutional network with a transformer architecture to capture residue interactions directly from the sequence.
Minjie Mou +14 more
wiley +1 more source
Nutritional quality and price of plant‐based dairy and meat analogs in the Canadian food supply system [PDF]
, 2023 Jennifer J. Lee +5 more
openalex +1 more source
A Wireless, Battery‐Free Artificial Throat Patch with Deep Learning for Emotional Speech Recognition
Advanced Science, EarlyView.In this work, Xu and co‐workers develop a wireless, battery‐free artificial throat patch system (ATPS) consisting of a carbon nanotube‐based thin‐film strain sensor and a miniaturized flexible printed circuit board, to enable real‐time sensing of throat signals.
Bingxin Xu +10 more
wiley +1 more source