Results 41 to 50 of about 47,337 (212)

MRSA HarboringmecA Variant GenemecC, France

Emerging Infectious Diseases, 2012
We describe human cases and clustered animal cases of mecA(LGA251)-positive methicillin-resistant Staphylococcus aureus in France. Our report confirms that this new variant has a large distribution in Europe. It may represent a public health threat because phenotypic and genotypic tests seem unable to detect this new resistance mechanism.
Frederic Laurent, Hubert Chardon, Marisa Haenni, Michele Bes, Marie-Elisabeth Reverdy, Jean-Yves Madec, Evelyne Lagier, François Vandenesch, Anne Tristan   +8 more
openaire   +3 more sources

A preliminary study of mecA gene expression and methicillin resistance in staphylococci isolated from the human oral cavity

Sri Lankan Journal of Infectious Diseases, 2019
Introduction: Staphylococci are common human commensals that acquire methicillin resistance via the mecA gene. Methicillin resistance in staphylococci from various clinical sources has been assessed using cefoxitin disc diffusion test (CDDT) and PCR ...
WMDA Wijesundara, RGSC Rajapakse, JAMA Jayatilake, JAMS Jayatilake   +3 more
doaj   +1 more source

Computational Screening of Approved Drugs for Inhibition of the Antibiotic Resistance Gene mecA in Methicillin-Resistant Staphylococcus aureus (MRSA) Strains

BioTech, 2023
Antibiotic resistance is a critical problem that results in a high morbidity and mortality rate. The process of discovering new chemotherapy and antibiotics is challenging, expensive, and time-consuming, with only a few getting approved for clinical use.
Benson Otarigho, Mofolusho O. Falade
doaj   +1 more source

Comparison of Real-Time PCR with Disk Diffusion, Agar Screen and E-test Methods for Detection of Methicillin-Resistant Staphylococcus aureus [PDF]

, 2010
Methicillin-resistant Staphylococcus aureus (MRSA) is a nosocomial pathogen. Our main objective was to compare oxacillin disk test, oxacillin E-test, and oxacillin agar screen for detection of methicillin resistance in S.
Karimi, Ali., Nafisi, Mohammad Reza., Shariati, Laleh., Tabatabaiefar, Mohammad Amin., Validi, Majid.   +4 more
core   +1 more source

Absence of meca gene in methicillin-resistant staphylococcus aureus isolates

African Journal of Infectious Diseases, 2010
Methicillin-resistant Staphylococcus aureus has emerged as a serious threat to public health, causing both hospital and community-associated infections. The gold standard for MRSA detection isthe amplification of the mecA gene that codes for the production of the altered penicillin-binding protein (PBP2a) responsible for classical methicillin ...
Olayinka, B.O, Olayinka, A.T, Obajuluwa, A.F, Onaolapo, J.A, Olurinola, P.F   +4 more
openaire   +3 more sources

Prevalence of mecC Gene in MRSA at A Tertiary Hospital in Medan, Indonesia

Journal of Pure and Applied Microbiology
Methicillin-resistant Staphylococcus aureus (MRSA) is resistant to β-lactam antibiotics owing to the presence of mecA and mecC resistance genes. Resistance genes in MRSA are carried by a genetic component named staphylococcal cassette chromosome mec ...
Fiola Elsabillah Amandani, Sri Amelia, Nurfida Khairina Arrasyid, Fera Wahyuni, Ridwan Balatif   +4 more
doaj   +1 more source

Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions

Nature Communications, 2017
Myoepithelial carcinoma (MECA) is a rare aggressive salivary gland cancer. Here, the authors analyze the genomic landscape of MECA and identify a high prevalence of oncogenic gene fusions, primarily PLAG1 fusions, highlighting TGFBR3-PLAG1 as a potential
Martin G. Dalin, Nora Katabi, Marta Persson, Ken-Wing Lee, Vladimir Makarov, Alexis Desrichard, Logan A. Walsh, Lyndsay West, Zaineb Nadeem, Deepa Ramaswami, Jonathan J. Havel, Fengshen Kuo, Kalyani Chadalavada, Gouri J. Nanjangud, Ian Ganly, Nadeem Riaz, Alan L. Ho, Cristina R. Antonescu, Ronald Ghossein, Göran Stenman, Timothy A. Chan, Luc G. T. Morris   +21 more
doaj   +1 more source

Development of rapid, automated diagnostics for infectious disease: advances and challenges [PDF]

, 2009
The last 2 years has seen an exponential rise in the amount of research funding made available for the development of rapid diagnostic devices for infectious agents of medical importance. This review reports on several such projects.
Ince, J, McNally, A
core   +1 more source

Immunomodulatory and Cytotoxic Properties of Enniatin B1 in Porcine Alveolar Macrophages

Journal of Applied Toxicology, EarlyView.
ABSTRACT This study investigates the immunomodulatory effects of Enniatin B1 (ENNB1), an emerging mycotoxin, on porcine alveolar macrophages (PAMs), a species‐specific model relevant to human innate immunity. PAMs were exposed to increasing ENNB1 concentrations (0.5–6 μM) over 6, 24, and 48 h.
Sara Frazzini, Francesca Caloni, Paola Fossati, Giancarlo Ruffo, Luciana Rossi   +4 more
wiley   +1 more source

Evaluation of FilmArray Multiplex PCR Test Results in Bloodstream Infections in Oncological Patients

Journal of Clinical Laboratory Analysis, EarlyView.
In this study conducted at an oncology hospital, BCID2 panel results for the rapid identification of microorganisms and resistance genes in positive blood culture samples were compared with conventional culture methods. The BCID2 panel provided faster results and showed a high correlation with traditional methods.
İpek Mumcuoğlu, Sevgi Şahin, Esra Tavukcu, Neşe İnan, Ayşe Semra Güreser, Serap Süzük Yıldız, Tuba Dal   +6 more
wiley   +1 more source