Results 261 to 270 of about 2,396,468 (298)

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Use of Mechanical Versus Biological Aortic Valve in Aortic Valve Replacement Surgery for Patients Aged 60-70 Years: A Systematic Review and Meta-Analysis. [PDF]

Cureus
Natasya N, Galea J, Khan H, Pagolu Y.
europepmc   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

Effect of technological parameters on mechanical properties and microstructure of heat-assisted friction stir welded joints of 6061 aluminum alloy. [PDF]

PLoS One
Nguyen HL, Pham VT, Luu DB, Tran TP.
europepmc   +1 more source

The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity

Molecular Oncology, EarlyView.
Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause, Rixa‐Mareike Köhn, Christian Ickes, Julia Lenger, Jonas Fischer, Sabrina Cappello, Ivan Bogeski   +6 more
wiley   +1 more source

Role of Femoral Anatomical Mechanical Angle in Getting Alignment in Total Knee Arthroplasty. [PDF]

J Orthop Case Rep
Yadav S, Ghorawat S, Chiranjeevi KP, Jadon AS, Pandey S.   +4 more
europepmc   +1 more source

Not just a by‐product: circular DNA molecules derived from V(D)J recombination are linked to worse prognosis in B‐cell leukemia

Molecular Oncology, EarlyView.
Gao et al. report that circular DNA molecules created as by‐products of V(D)J recombination during lymphocyte maturation (ESCs) can replicate and be retained for much longer than previously thought in healthy cells. In BCP‐ALL cells, increased ESC abundance correlates with a greater chance of relapse likely mediated by their ability to induce genome ...
Davide Pradella, Andrea Ventura
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

History and Application of Mechanical Assist Devices as a Bridge to Heart Transplant: A Review and Perspectives in Brazil. [PDF]

Braz J Cardiovasc Surg
Perazzo A, Gaiotto FA, Steffen SP, Gaspar SFD, Faria VS, Ferreira RCS, Carbonera A, Guazzelli DL, Gamboa JAR, Ideal LF, Gomes HL, Falcão ATG, Fernandes AL, Campos LH, Steffen CL, Limongi C, Varjão RL, Avila MS, Seguro LFBDC, Mangini S, Marcondes-Braga FG, Aulicino GB, Campos IW, Santos RHB, Lourenço DD, Kowalewski M, Ronco D, Matteucci M, Meani P, Russo CF, Mauro MD, Mariani S, Loforte A, Wiedmann D, Bacal F, Whitman G, Punjabi P, Lorusso R, Jatene FB.   +38 more
europepmc   +1 more source

Safety and effectiveness of catheter ablation of atrial fibrillation in patients with mitral valve replacement mechanical versus bioprosthetic valves. [PDF]

Sci Rep
Liu XY, Long DY, Dong JZ, Du X, Sang CH, Yu RH, Jiang CX, Liu N, Li SN, Wang W, Guo XY, Zhao X, Li CY, Zuo S, Li MM, Jia CQ, Jiang YX, Lv WH, Wu ZY, Li YK, Wang XS, Du ZH, Tang RB, Ma CS.   +23 more
europepmc   +1 more source