Results 261 to 270 of about 6,806,810 (337)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Bedside detection of end-tidal overdistention: an exploratory comparison of loading maneuvers. [PDF]

Intensive Care Med Exp
Kummer RL, Thornton LT, Selickman JE, Elmufdi FS, Crooke PS, Marini JJ.   +5 more
europepmc   +1 more source

Dynamic characteristics of a two-phase mechanically pumped cooling loop for avionics

S. Qi, Zhaohao Xu, Jiale Wang, Yu Xu
openalex   +1 more source

Thermo-mechanical and micro-structural properties of xylanase containing whole wheat bread

, 2016
Gargi Ghoshal, U. S. Shivhare, Uttam Chand Banerjee   +2 more
openalex   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Cell Adhesion and Biofilm Development via Force-Sensitive Mechanisms: A Perspective. [PDF]

ACS Biomater Sci Eng
Karim MA, KianvashRad N, Cabo M, Adegoke SC, Tuffour K, Duah R, Yawlui ISY, Lajeunesse D.   +7 more
europepmc   +1 more source

Effect of moisture absorption on the mechanical behavior of banana-bamboo-glass fiber reinforced hybrid composites in NaCl solution

Farhana Akter Mim
openalex   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Study on evaluation method for hydromechanical properties of hard and brittle shale based on indentation hardness. [PDF]

Sci Prog
Cui S, Jianfa W, Zeng B, Huang H, Chen L, Liu H, Zhang Z.   +6 more
europepmc   +1 more source