Results 91 to 100 of about 438,222 (313)
The mechanism of Torsin ATPase activation [PDF]
Proceedings of the National Academy of Sciences, 2014 Significance Torsin activity critically depends on accessory cofactors that activate their ATPase activity by a poorly understood mechanism. This study establishes the mechanistic framework for Torsin activation, which relies on a complementation of the fragmentary Torsin active site.
Rebecca S H, Brown +4 more
openaire +2 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Modulation of cell-matrix adhesions to affect mechanotransduction [PDF]
, 2010 In cultured fibroblasts three types of cell-matrix adhesion with specific cellular localization and protein composition can be distinguished: focal complexes, focal adhesions and fibrillar adhesions.
Lutz, Roman
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Mechanical muscle properties and intermuscular coordination in maximal and submaximal cycling: theoretical and practical implications [PDF]
, 2014 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel UniversityThe ability of an individual to perform a functional movement is determined by a range of mechanical properties including the force and power producing ...
Barratt, Paul
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Mechanical Activation of Solids in Extractive Metallurgy [PDF]
, 2008 Mechanochemistry is the branch of chemistry that has primarily evolved in the twentieth century.It deals with the field of reactions caused by mechanical energy, often referred to as Mechanical or Mechanochemical Activation [1-3].
Alex, T C, Kumar , Sanjay, Kumar, Rakesh
core
, 2011 Progressive alterations in cardiac wall strains are a classic hallmark of chronic heart failure. Accordingly, the objectives of this study are to establish a baseline characterization of cardiac strains throughout the cardiac cycle, to quantify temporal,
John-Peder Escobar Kvitting +11 more
core +1 more source
Mechanical Activation on Bioleaching of Chalcopyrite: A New Insight
, 2020 Mechanical activation as a means of accelerating the mineral dissolution may play an important role in chalcopyrite bioleaching. In the present work, the mechanical activation by ball-milling with 10 min, 30 min, 60 min, 90 min, 120 min and 180 min time ...
Yu-Hang Zhou +7 more
core +1 more source