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Mechanisms of plasminogen activation
Journal of Internal Medicine, 1994The fibrinolytic system consists of an inactive proenzyme, plasminogen, that is converted by plasminogen activators to the active enzyme, plasmin, that degrades fibrin. Two immunologically distinct plasminogen activators have been identified: tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA).
H R, Lijnen +6 more
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Annual Review of Biochemistry, 2015
The ataxia-telangiectasia mutated (ATM) protein kinase is a master regulator of the DNA damage response, and it coordinates checkpoint activation, DNA repair, and metabolic changes in eukaryotic cells in response to DNA double-strand breaks and oxidative stress.
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The ataxia-telangiectasia mutated (ATM) protein kinase is a master regulator of the DNA damage response, and it coordinates checkpoint activation, DNA repair, and metabolic changes in eukaryotic cells in response to DNA double-strand breaks and oxidative stress.
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MECHANISMS OF ZYMOGEN ACTIVATION
Annual Review of Biophysics and Bioengineering, 1977It is now well recognized that proteolytic enzymes play key roles in the regulation of or control over the action of other proteins (1-3). Such enzymes can be found in all species from bacteria to man and in control of diverse systems, which include hormone production, bacteriophage assembly (4), development, fertilization (5), digestion, defense ...
R M, Stroud +2 more
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The mechanism of the activation of papain
Biochemical and Biophysical Research Communications, 1969Abstract The predominant form of inactive papain prepared by the method of Kimmel and Smith (1) is shown to be a mixed disulfide formed between a sulfhydryl group on the enzyme and cysteine. Reduction or other nucleophilic cleavage of this bond frees the active thiol of papain and stoichiometric amounts of free cysteine or cysteine whose sulfur atom ...
I B, Klein, J F, Kirsch
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Mechanisms of caspase activation
Current Opinion in Cell Biology, 2003The core effectors of apoptosis encompass proteolytic enzymes of the caspase family, which reside as latent precursors in most nucleated metazoan cells. A majority of studies on apoptosis are based on the assumption that caspase precursors are activated by cleavage, a common mechanism for most protease zymogen activations.
Kelly M, Boatright, Guy S, Salvesen
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Study on mechanism of mechanical activation
Materials Science and Engineering: A, 1997A mixture of ilmenite and graphite with a mass ratio (1:1) was ball milled at room temperature and subsequently annealed under Ar flow. The enhanced carbothermic reactions were monitored by using thermogravimetric analysis and X-ray diffraction analysis.
Y. Chen +3 more
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The mechanics of active muscle
Proceedings of the Royal Society of London. Series B - Biological Sciences, 1953Abstract When a frog’s or toad’s sartorius is rapidly released during a maintained isometric contraction its tension drops immediately and is redeveloped later. The extent of release required to reduce the tension to zero is 3 to 4 % of the length of the muscle.
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Destruction mechanism of casting graphite in mechanical activation
CIS Iron and Steel Review, 2018Текст статьи не публикуется в открытом доступе в соответствии с политикой журнала.
I. E. Illarionov +4 more
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Science, 1995
S. Buratowski discusses two papers in this issue of Science (Sauer et al ., pp. 1783 and 1825 ) that show that the basal transcription factor complex TFIID is a target of transcriptional activators.
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S. Buratowski discusses two papers in this issue of Science (Sauer et al ., pp. 1783 and 1825 ) that show that the basal transcription factor complex TFIID is a target of transcriptional activators.
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