Results 41 to 50 of about 2,657,709 (249)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Practical implementation of the durability index-based performance approach [PDF]
, 2012 Includes abstract.Includes bibliographical references.The purpose of this study was to examine the validity of Durability Index (DI) based performance specifications as a practical approach in the control of quality, with regard to durability, in ...
Nganga, Gladwell Wanjiku
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Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Collusion and Durability [PDF]
We develop a model to show that cartels that produce goods with lower durability are easier to sustain implicitly. This observation gen- erates the following results: 1) implicit cartels have an incentive to pro- duce goods with an inefficiently low ...
Strausz, Roland, Sasaki, Dan
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Results in EngineeringAlong with corrosion, erosion is one of the main causes of damage to civil infrastructures. The continuous impact of fine particles carried by the air produces a deterioration in the elements of these structures.
Rocío Cortés +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
An Overview of Durability Evaluations of Elastomer-Based Magnetorheological Materials
IEEE Access, 2020 Most parts of the failures in structural elements in use were consequences of mechanical durability. Therefore, durability had been one of the critical factors to be considered in designing durable mechanical elements.
Mohd Aidy Faizal Johari +7 more
doaj +1 more source
Mechanical and durability assessment of concrete containing seashells: A review
Cogent Engineering, 2021 This study reviews recent literature on the mechanical and durability properties of concrete incorporating seashells as partial or full substitutes for conventional materials.
Gideon Bamigboye +5 more
doaj +1 more source
Buildings, 2022 In recent times, the applications of fiber-reinforced recycled aggregate concrete (FRAC) in practical engineering have gained greater popularity due to its superior mechanical strength and fracture properties.
Wisal Ahmed, C. W. Lim, Arslan Akbar
doaj +1 more source