Results 91 to 100 of about 2,379,090 (281)

Engineering design project : series 2 [PDF]

open access: yes, 2017
This book is a compilation of engineering design projects which illustrates a detail explanation on the design process including all tools and methods involved in each design stage.

core  

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

open access: yesFEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello   +6 more
wiley   +1 more source

Machine Design Experiments Using Gears to Foster Discovery Learning [PDF]

open access: yes, 2015
Machine Design Experiments Using Gears to Foster Discovery Learning For the typical undergraduate engineering student the topic of gears is introduced and discussed in several courses.
Nagurka, Mark L.   +1 more
core   +1 more source

Agustín de Betancourt’s Double-Acting Steam Engine: Analysis through Computer-Aided Engineering

open access: yesApplied Sciences, 2018
This article analyses the double-acting steam engine designed by Agustín de Betancourt in 1789 and based on the steam engine of James Watt. Its novelty and scientific interest lies in the fact that from the point of view of industrial archaeology and the
José Ignacio Rojas-Sola   +1 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

Mechanical dissection in an introductory engineering design module [PDF]

open access: yes, 2010
The introductory design module for first year students in the Department of Mechanical Engineering at the University of Strathclyde uses mechanical dissection as a focus for learning activities that seek to integrate engineering science with the prior ...
Jenkins, Peter, McLaren, A.J.
core  

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

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