Results 61 to 70 of about 665,980 (290)

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Revisiting classical design in engineering from a perspective of frugality

Heliyon, 2017
The conservative nature of design in engineering has typically unleashed products fabricated with generous amounts of raw materials. This is epitomized by the factor of safety whose values higher than unity suggests various uncertainties of design that ...
Balkrishna C. Rao
doaj  

A Crowdsourcing Engine for Mechanized Labor [PDF]

Proceedings of the Institute for System Programming of the RAS, 2015
Crowdsourcing is an established approach for producing and analyzing data that can be represented as a human-assisted computation system. This paper presents a crowdsourcing engine that makes it possible to run a highly customizable hosted crowdsourcing platform controlling the entire annotation process including such elements as task allocation ...
openaire   +5 more sources

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Numerical investigation of heat transfer in parallel channels with water at supercritical pressure

Heliyon, 2017
Thermal phenomena such as heat transfer enhancement, heat transfer deterioration, and flow instability observed at supercritical pressures as a result of fluid property variations have the potential to affect the safety of design and operation of ...
Edward Shitsi, Seth Kofi Debrah, Vincent Yao Agbodemegbe, Emmanuel Ampomah-Amoako   +3 more
doaj  

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

High-temperature quality of accelerated spheroidization on SUP9 leaf spring to enhance machinability

Heliyon, 2018
The high temperature on the austenitization showed the varied results in the fast spheroidization in high carbon leaf spring steel SUP9/55CrMnA. The heating temperature was held for 15 minutes in the austenitization temperature at 800, 850, and 900 °C ...
Hendri Chandra, Diah Kusuma Pratiwi, Muhammad Zahir   +2 more
doaj  

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

Development of an electrolysis based system to continuously recover magnesium from seawater

Heliyon, 2018
The continuous resources recovery system utilizing the water electrolysis reaction was developed for recovering magnesium resources from seawater. A set of experiments for forming magnesium hydroxide from the deep-ocean water were carried out at a ...
Yoshihiko Sano, YiJia Hao, Fujio Kuwahara   +2 more
doaj