Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha+6 more
wiley +1 more source
Revisiting classical design in engineering from a perspective of frugality
The conservative nature of design in engineering has typically unleashed products fabricated with generous amounts of raw materials. This is epitomized by the factor of safety whose values higher than unity suggests various uncertainties of design that ...
Balkrishna C. Rao
doaj
Mechanics 4.0 and Mechanical Engineering Education
Industry 4.0 is an industrial paradigm that is causing changes in form and substance in factories, companies and businesses around the world, and is impacting work and education in general. In fact, the disruptive technologies that frame the fourth industrial revolution have the potential to improve and optimize manufacturing processes and the entire ...
Eusebio Jiménez López+6 more
openaire +2 more sources
A Crowdsourcing Engine for Mechanized Labor [PDF]
Crowdsourcing is an established approach for producing and analyzing data that can be represented as a human-assisted computation system. This paper presents a crowdsourcing engine that makes it possible to run a highly customizable hosted crowdsourcing platform controlling the entire annotation process including such elements as task allocation ...
openaire +5 more sources
Multi-Color Cavity Ringdown Based Detection Method and Apparatus [PDF]
A multi-color cavity ringdown based spectrometer is housed in a light tight enclosure to detect the presence of trace quantities of gas phase molecules emanating from explosives, drugs, or hazardous materials being transported through the enclosure or ...
Allen, Susan, Reeve, Scott
core +1 more source
Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi+6 more
wiley +1 more source
Numerical investigation of heat transfer in parallel channels with water at supercritical pressure
Thermal phenomena such as heat transfer enhancement, heat transfer deterioration, and flow instability observed at supercritical pressures as a result of fluid property variations have the potential to affect the safety of design and operation of ...
Edward Shitsi+3 more
doaj
Experience in engineering of scientific software: The case of an optimization software for oil pipelines [PDF]
Development of scientific and engineering software is usually different and could be more challenging than the development of conventional enterprise software. The authors were involved in a technology-transfer project between academia and industry which focused on engineering, development and testing of a software for optimization of pumping energy ...
arxiv
Near-Field Thermal Radiative Transfer and Thermoacoustic Effects from Vapor Plumes Produced by Pulsed CO/sub 2 /Laser Ablation of Bulk Water [PDF]
Submillimeter deep heating of bulk water by thermal radiation from ablative water plumes produced by a 10.6 μm transversely excited atmospheric C O2 laser and the related acoustic generation has been studied using a contact time-resolved photoacoustic ...
Allen, S. D.+2 more
core +1 more source
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić+31 more
wiley +1 more source