Results 111 to 120 of about 5,213 (312)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Design and fabrication of microfluidic food spoilage sensor

, 2014
Microfluidic paper-based devices (micropads) are an advancing research area offering real-time analysis which utilizes only microlitre volumes of fluids.
Sim, Yan Lim
core  

A review of intrinsic self-healing capability of engineered cementitious composites: Recovery of transport and mechanical properties

Construction and Building Materials, 2015
Abstract The need for viable materials in sustainable infrastructures is driving the creation of multifunctional strain-hardening cementitious composites that combine brittle cementitious matrices with fibers. Unlike conventional concrete, these materials typically show multiple microcracking behavior with strain-hardening response under tensile ...
Yildirim, Gurkan, Keskin, Ozlem Kasap, Keskin, Suleyman Bahadir, Sahmaran, Mustafa, Lachemi, Mohamed   +4 more
openaire   +3 more sources

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Calibration of the Intelligent Driver Model (IDM) at the Microscopic Level

Future Transportation
This paper presents a calibration technique for the Intelligent Driver Model (IDM), a car-following model that considers the physical interpretation of each parameter. Using an instrumented vehicle, trajectory data were gathered for a group of Portuguese
Luís Vasconcelos, Jorge M. Bandeira
doaj   +1 more source

Altering the Course of Technologies to Monitor Loosening States of Endoprosthetic Implants

Sensors, 2019
Musculoskeletal disorders are becoming an ever-growing societal burden and, as a result, millions of bone replacements surgeries are performed per year worldwide.
João Henrique Cachão, Marco P. Soares dos Santos, Rodrigo Bernardo, António Ramos, Rainer Bader, Jorge A. F. Ferreira, António Torres Marques, José A. O. Simões   +7 more
doaj   +1 more source

Harnessing prokaryotic amino acid transporters for metabolic engineering: mechanisms and biotechnological applications

Synthetic and Systems Biotechnology
As fundamental bioactive molecules and building blocks of cellular structures, amino acids play a crucial role in sustaining life, reflected in a global market valued at tens of billions of dollars. Recently, microbial fermentation has become a leading alternative to chemical synthesis and enzymatic catalysis for amino acid production, driving the need
Junyao Huang, Wenming Wu, Zhicheng Fu, Chunyu Chao, Chongde Lai, Xiaoyu Wu, Hui Yang, Xiaohe Chu, Bangce Ye, Bin Zhang   +9 more
openaire   +2 more sources

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

"Sump-Inlet" deployment linkage design for sargassum ocean sequestration (SOS)

, 2019
Thesis: S.B., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2019Cataloged from PDF version of thesis.Includes bibliographical references (page 42).Invasive floating sargassum seaweed has become a serious problem for ...
Bockman, Samuel Jacob.
core