Results 151 to 160 of about 5,213 (312)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Convective effects on head-on quenching of premixed flames in a stagnation flow
Head-on quenching (HOQ) is one of the canonical configurations of flame-wall interaction (FWI), where a premixed flame propagates at a normal angle to the wall and quenches.
YOKOMORI, Takeshi +3 more
core +1 more source
Applied SciencesCavitation erosion is a critical problem for many engineering components, such as ship propellers, diesel engine exhaust valves, cylinder liners, pump impeller blades, hydraulic turbines, and bearings, which are exposed to high-velocity flowing fluids or
Ion Mitelea +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Cathodes pinpoints for the next generation of energy storage devices: the LiFePO4 case study
JPhys MaterialsThere are still essential aspects regarding cathodes requiring a comprehensive understanding. These include identifying the underlying phenomena that prevent reaching the theoretical capacity, explaining irreversible losses, and determining the cut-off ...
Beatriz Arouca Maia +4 more
doaj +1 more source
Special issue on process and mechanical engineering for carbon capture and transport [PDF]
Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering, 2013 Meihong Wang, Adekola Lawal
openaire +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
International audienceThis article offers an in-depth exploration of virtual reality (VR) as an emerging technology in mechanical engineering education, drawing on its implementation at the Arts et Metiers campus in Metz. It highlights a range of student-
Klein, Guillaume +2 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source