Results 81 to 90 of about 366,306 (360)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Shock and Vibration, 2009 Fluid film journal bearings (FFBs) are used to support high-speed rotors in turbomachinery which often operate above the rotor first bending critical speed.
T.W. Dimond +3 more
doaj +1 more source
The Recovery of Weak Impulsive Signals Based on Stochastic Resonance and Moving Least Squares Fitting [PDF]
, 2014 In this paper a stochastic resonance (SR)-based method for recovering weak impulsive signals is developed for quantitative diagnosis of faults in rotating machinery.
Fengshou Gu +19 more
core +2 more sources
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Monitoring the Joint Area of Composite Membrane Materials
Applied Sciences, 2019 Textile membranes are suitable for a wide range of applications due to their user-adjustable properties, which can be modified based on both the textile reinforcement structure and the coating material. Complex dynamic loads are involved in typical usage
Hans Winger +5 more
doaj +1 more source
Machine Learning Analysis in Mechanical Engineering
Computers and artificial intelligenceDespite the rapid development of the AI industry and the programming industry in the machinery manufacturing or production industry, there is no systematic explanation as to why the use of machine learning can enhance the development of related ...
Huangyu Zhao
semanticscholar +1 more source
5th International Conference on Materials Science, Machinery and Energy Engineering (MSMEE 2023)
Highlights in Science Engineering and Technology, 2023 2023 5th International Conference on Materials Science, Machinery and Energy Engineering (MSMEE 2023) was successfully held from 25 to 26, February, 2023 in Rio, Brazil. The conference was jointly organized and sponsored by Harbin Institute of Technology
Yuqing Jiang, Augus Cromwell
semanticscholar +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Review of current knee biomechanical modeling techniques [PDF]
, 2011 In this paper we are going to present an essential modification of an existing analytical model. The model creation normally starts with a simplified, less complex analytical model, where the phenomena can be easily interpreted, checked and controlled ...
Abdel Wahab, Magd +3 more
core +1 more source
Prioritization of hazards by means of a QFD-based procedure [PDF]
, 2018 Despite the evolution of regulations in the field of occupational health and safety promoted in EU countries, the number of accidents and victims has not significantly decreased in recent years, especially in constructions and agriculture sectors, as ...
Fargnoli, Mario, Lombardi, Mara
core +1 more source