Results 61 to 70 of about 3,578,319 (247)

Controllable branching of robust response patterns in nonlinear mechanical resonators

Nature Communications, 2023
Feedback control applied to mechanical resonators can lead to the formation of various complex dynamic behaviors. Here the authors demonstrate flexible and controllable switching between dynamical structures in the response of harmonically driven micro ...
Axel M. Eriksson, Oriel Shoshani, Daniel López, Steven W. Shaw, David A. Czaplewski   +4 more
doaj   +1 more source

Development of a force-feedback laparoscopic surgery simulator [PDF]

, 1999
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1999.Includes bibliographical references (p. 77-78).The work presented here addressed the development of an electro-mechanical force-feedback device to provide more ...
Ben-Ur, Ela
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

User feedback on prototypes and its impact on the success of future products [PDF]

, 2010
Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2010.Cataloged from PDF version of thesis.Includes bibliographical references (p.
Beyer, Alexandra M. (Alexandra Melanie)
core  

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

The Impact of Mechanical Feedback on Correcting Errors in Overhead Volleyball Serve Performance [PDF]

Annals of Applied Sport Science
Background. It is challenging to master the overhead serve in volleyball because of the several ways of positioning the body correctly when hitting the ball and the toss.
Manaf Majid Hassan, Hameed Hammad Khalaf, Omar Ahmed Mosleh, Waleed Khalid Hammadi, Shakir Mahmood Abdullah   +4 more
doaj  

Two-axis haptic force feedback joystick

, 2015
Thesis: S.B., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2015.Cataloged from PDF version of thesis.Includes bibliographical references (pages 46-47).The development of multi-axis force feedback joysticks enables ...
Pritchett, Will (Will Grey)
core  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Almost Global Stabilization of Curvature-Nullifiable Mechanical Systems via Pure Mechanical Feedback

Applied Sciences
Mechanical control systems structure, derived from Euler–Lagrange dynamics, is directly tied to physically meaningful coordinates such as joint angles, positions, and velocities. This work investigates when a mechanical control system can be transformed,
Marta Drążkowska, Marcin Nowicki
doaj   +1 more source

Predictive feedback control and Fitts' law [PDF]

, 2008
Fitts’ law is a well established empirical formula, known for encapsulating the “speed-accuracy trade-off”. For discrete, manual movements from a starting location to a target, Fitts’ law relates movement duration to the distance moved and target size ...
Loram, I., Gawthrop, P, Loram, I, Lakie, M., Lakie, Martin, Gawthrop, P.J.   +5 more
core   +1 more source