Results 81 to 90 of about 164,242 (252)
Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen +9 morewiley +1 more sourceA novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz +9 morewiley +1 more sourceA self-mixing laser sensor design with an extended kalman filter for optimal online structure analysis and damping evaluation [PDF]
, 2007 We have developed a new algorithm based on the extended Kalman filter, in order to improve the resolution of an optical displacement sensor. This new non contact sensor which provides vibration measurement with a very good accuracy might be used for ...Bès, Caroline, Gourinat, Yves, Belloeil, Victorien, Plantier, Guy, Bosch, Thierry +4 morecore +1 more sourcePAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann +10 morewiley +1 more sourceIn vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer +8 morewiley +1 more sourceTranslating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD) Sejung Lee, Junghyeok Lim, Jinhyuk Bhinwiley +1 more sourceObservation of a kilogram-scale oscillator near its quantum ground state [PDF]
, 2009 We introduce a novel cooling technique capable of approaching the quantum ground state of a kilogram-scale system—an interferometric gravitational wave detector.Blair, D, Murray, P, Degree, M, Khalili, F., Gretarsson, A M, Hosken, D, Strom, D. M., McKechan, D, Cagnoli, G., Pinto, I. M., Mitra, S, Sigg, D, DeBra, D, Blair, D., Weinstein, A, Sutton, P. J., Hennessy, M, Trias, M, Williams, H R, Takahashi, H., Buonanno, A, Mageswaran, M, Ottens, R. S., Pedraza, M., Lang, M M, Hanna, C., Sibley, A., Worden, J., Frolov, V V, Tokmakov, K.V., Müller-Ebhardt, H, Numata, K., Lam, P., Thuring, A., McCarthy, R., Ju, L, Sears, B, Dwyer, J. G., Ingram, D, Nelson, J., Cunningham, L., Parameshwaraiah, V, Evans, T, Schilling, R, Harms, J, Leonor, I, Billingsley, G, Pankow, C., Giampanis, S, Byer, R., Lockerbie, N. A., Romano, J D, Rogan, A. M., Raab, F, Hirose, E, Allen, G, Williams, H.R., Principe, M, Pitkin, M., Scott, S.M., Allen, B, Degree, M., Fotopoulos, N, Kwee, P., Duke, I., Yamamoto, H, Riles, K, Heng, I.S., Sakata, S., Kawazoe, F, McClelland, D.E., Brady, P R, Papa, M.A., Aso, Y, O'Reilly, B, Melissinos, A, Sung, M., Matzner, R., Thacker, J., Dupuis, R., Grunewald, S, Jones, D.I., Casebolt, T, Kalmus, P., Bogue, L., Debra, D., Christensen, N, Hosken, D., Dupuis, R J, Johnson, B, Maros, E, Hayama, K., Khan, R, Kalmus, P, Smith, J., Heefner, J., Kissel, J. S., Cepeda, C., Zhao, C., Dhurandhar, S., Sakata, S, Armor, P, Dergachev, V, Whiting, B F, Melissinos, A., Ballmer, S, Harry, G., Kopparapu, R.K., Brooks, A., Thorne, K.A., Flasch, K, Bodiya, T., Fricke, T, Sathyaprakash, B., Cutler, R M, Schediwy, S. W., Mailand, K, Traylor, G., Frolov, V.V., van der Sluys, M, Stein, L. C., Murray, P., Romie, J., Mueller-Ebhardt, H., Mukhopadhyay, H., Chalkley, E, Kawabe, K, Ju, L., Samidi, M, Echols, C., McIvor, G, McIntyre, G., Brady, P., Schutz, B.F., Ward, H., Charlton, P, Huttner, S H, Khalili, F. Ya., Torres, C., Wette, K, Schutz, Bernard Frederick, Sathyaprakash, B.S., Bayer, K., Wooley, R., Robinson, Craig Anthony, Rabeling, D., Gustafson, E K, O'Reilly, B., Roddy, S, Zweizig, J, Kamat, S, Mendell, G, Villar, A., Robertson, N., Thorne, K. A., Hennessy, M., Harry, G, McIvor, G., Degallaix, J, Robinson, E L, Duke, I, Stuver, A, de la Jordana, L.S., Anderson, S. B., Anderson, S., Barr, B, Fyffe, M., Wen, S., Hayler, T, Sellers, D., McClelland, D., Barish, B., Kanner, J, Etzel, T, Wu, W, Petrie, T, Garofoli, J, Nishizawa, A., Schediwy, S W, Messenger, C., Torrie, C, Route, R., Sears, B., González, G., Ramsunder, M., Riesen, R., Grosso, R, Fan, Y, Ito, M, Van Den Broeck, C., Meshkov, S, Leindecker, N., Barton, M., Harms, J., Myers, J., Dietz, A., Drever, R.W.P., Winkler, W., Takahashi, H, Postiglione, F., Gustafson, E., Anderson, W G, Strain, K A, McClelland, D. E., Dietz, A, Kawazoe, F., Whitcomb, S E, Ottaway, D J, Ehrens, P., Mitra, S., Fritschel, P, Gossler, S, Grote, H., Markosyan, A., Fairhurst, Stephen, Mossavi, K, Wipf, C C, McGuire, S. C., Robinson, E. L., Espinoza, E, Mueller, G, Petrie, T., Sancho de la Jordana, L, Ito, M., Riles, K., Schofield, R, Stein, L C, McIntyre, G, Tanner, D.B., Mason, K, Sutton, Patrick J., Wooley, R, Strain, K.A., Tyler, W., Fejer, M. M., Abbott, B. P., Kopparapu, R., Mavalvala, N, Hough, J, Penn, S., Sandberg, V, Etzel, T., Quetschke, V, Díaz, M, Huttner, S.H., Anderson, W., Slagmolen, B., Mukherjee, S, Tanner, D B, Patel, P., Messenger, C. J., Smith, M R, Myers, E., Lang, M.M., Rakhmanov, M., Finn, L., Rehbein, H, Klimenko, S, Rüdiger, A, Waldman, S. J., Boschi, V, Barish, B. C., Dietz, Alexander, Wiseman, A.G., Brady, P. R., Bland, B, Fazi, D., Cannizzo, J., Ugolini, D., Creighton, J., Mason, K., Stochino, A, Weinert, M, Gustafson, E.K., Beyersdorf, P.T., Veitch, J, Brown, D., Kissel, J S, Veitch, P, Cutler, R.M., Willke, B., Ehrens, P, Numata, K, Ryan, K., Pletsch, H.J., Romano, J. D., Pankow, C, Aulbert, C., Rowan, S, Marx, J. N., Hage, B, Lubinski, M., Anderson, W.G., Veitch, J., Huttner, S. H., Danzmann, K, Aston, S, Moe, B, Matichard, F., Shawhan, P, Mukhopadhyay, H, Grimaldi, F., Minelli, J, Sengupta, A S, Giampanis, S., Araya, M, Machenschalk, B, Heng, I S, Scott, S. M., González, G, Dooley, K., Leonhardt, V, Hayler, T., Rivera, B., Slagmolen, B. J. J., Flasch, K., Hanson, J., Sigg, D., McKechan, D., Dhurandhar, S, Strom, D M, Lucianetti, A., Moe, B., Whelan, J. T., Luck, H., Schutz, B F, Schutz, B., Kopparapu, R K, Sancho de la Jordana, L., Tokmakov, K. V., Hirose, E., Mohanty, S., Shawhan, P., Davies, G, Mittleman, R, Sintes, A., Mitselmakher, G., Beyersdorf, P. T., Dooley, K.L., Martin, R. M., Bland, B., Cardenas, L., Slagmolen, B J J, Pinto, I M, DeSalvo, R., Vass, S, Williams, L, Fyffe, M, Sathyaprakash, Bangalore Suryanarayana, Kawamura, S, Armor, P., Saulson, P., Lang, M. M., Perreca, A, Russell, P, Munch, J., Lang, M., Smith, J. R., Corbitt, T., Harstad, E., Owen, B. J., Biswas, R., Coyne, D, Aston, S., Searle, A. C., King, P, McKenzie, K, Willems, P. A., Ivanov, A, Sengupta, A., Ugolini, D, Brau, J., Sorazu, B, Lubinski, M, Tokmakov, K V, Jones, D. I., Weinert, M., Schofield, R., Brown, D. A., Van Den Broeck, Chris, O'Dell, J., Sinha, S., Fejer, M.M., Reitze, D., Finn, L. S., Fejer, M M, Dalrymple, J, Giaime, J A, Bose, S, Nash, T, Papa, M A, Rollins, J., Robertson, N.A., Dickson, J., Vahlbruch, H, Burmeister, O., Barish, B C, Kalogera, V, Khalili, F Ya, Cokelaer, T., Vyatchanin, S., Hallam, J. M., Seifert, F, Libbrecht, K., Fritschel, P., Machenschalk, B., Veitch, P., Lin, H, Sathyaprakash, B. S., Matichard, F, Ruet, L, Lormand, M., Weinstein, A., Jones, D I, Hammer, D., Whiting, B. F., Dickson, J, Wiseman, A. G., Ward, H, Amin, R., Williams, H., Christensen, N., Siemens, X, Mow-Lowry, C., Braginsky, V B, Creighton, J D E, Grote, H, Rivera, B, O'Dell, J, Rogan, A.M., Krishnan, B., Vecchio, A, Chatterji, S, Miyakawa, O., Stein, L., Amin, R, Sun, K. -X., Doomes, E., Owen, B., Pletsch, H J, Dupuis, R.J., Strom, D., Cao, J., Mow-Lowry, C, Rabeling, D.S., Thorne, K.S., Frolov, V. V., Sintes, A. M., Brau, J. E., Giaime, J.A., Plissi, M. V., Mercer, R A, Gras, S., Zweizig, J., Marx, J.N.., Rollins, J, Leonhardt, V., Johnson, W., Lormand, M, Lantz, B, Tyler, W, Sutton, P., Mossavi, K., Rodriguez, A., Mitrofanov, V., Creighton, J.D.E., Greenhalgh, R.J.S., Quetschke, V., Sengupta, A. S., Mercer, R.A., Minelli, J., Cook, D., Hallam, J M, Armandula, H., Bose, S., Savage, R., Davies, Geraint, Jones, D., Scott, S., Clark, D, Mandic, V., Ward, R, Markosyan, A, Martin, I, Searle, A.C., Jones, R, Clark, J, Cadonati, L., Wiseman, A., Winkler, W, Schediwy, S.W., Williams, L., Wipf, C.C., Raab, F., Khazanov, E, Lodhia, D., Castaldi, G., Bilenko, I.A., McGuire, S.C., Blackburn, L, Cutler, R., Blackburn, K, Searle, A C, Stuver, A., Munch, J, Dooley, K. L., Chen, Y., Kasprzyk, D, Mueller, G., Dumas, J., Cannizzo, J, Perreca, A., Sandberg, V., Kozak, D, Heptonstall, A., Barish, B.C., Ogin, G., Whitcomb, S.E., Fotopoulos, N., Kamat, S., Jones, G, Keppel, D.G., Danilishin, S., Fehrmann, H., Whitcomb, S., Jones, G., Markowitz, J, Dooley, K L, Russell, P., Kokeyama, K., Ward, R., Cunningham, L, Schediwy, S., Bilenko, I., Sannibale, V, Chelkowski, S, Giaime, J. A., Miao, H, Sun, K-X, Heptonstall, A, Marx, J N, Vyatchanin, S.P., Márka, S, Ballmer, S., Sarin, P., Ulmen, J., Doomes, E E, Lockerbie, N.A., Mavalvala, N., Worden, J, Marka, Z., Sun, K.X., Donovan, F., Miller, J., Romano, J., Márka, Z, Sengupta, A.S., Taylor, J., Meier, T, Diaz, M., Gray, M, Schwinberg, P., Yan, Z, Bastarrika, M, Taylor, R, DeSalvo, R, Kawamura, S., Mitselmakher, G, Papa, M. A., Lam, P. K., Vass, S., Gray, C, Camp, J.B., Frey, R., Zhao, C, Cumming, A., Ottens, R., Bodiya, T. P., Penn, S, Effler, A., Meyers, D., Traylor, G, Wen, S, Danilishin, S, Camp, J B, Bodiya, T P, Slutsky, J, Aulbert, C, Kondrashov, V., Tanner, D., Frolov, V., Hanson, J, Anderson, S.B., Cannon, K, Owen, B J, Strain, K. A., Charlton, P., Thorne, K., Martin, R., Whitcomb, S. E., Reitze, D. H., Harstad, E, Drever, R. W. P., Reitze, D H, Hallam, J.M., King, P., McKechan, David, Camp, J. B., Meier, T., Messenger, C J, Nelson, J, Pitkin, M, Giardina, K.D., Nishizawa, A, Smith, N D, Shoemaker, D H, Slagmolen, B.J.J., Coyne, D., Lazzarini, A., Miyakawa, O, Zhang, L, Rainer, N, Lodhia, D, Zhang, J, Rogan, A., Bodiya, T.P., Fairhurst, S., Bilenko, I. A., Castaldi, G, Bullington, A, Grosso, R., Tanner, D. B., Prix, R, Wallace, L., Myers, E, Robinson, E.L., Cepeda, C, Saraf, S, MacInnis, M., Myers, J, Messenger, Christopher, Brau, J E, Keppel, D. G., Dumas, J-C, Vaulin, R., Matzner, R, Summerscales, T., Fazi, D, Robinson, C, Freise, A, Marka, S., Doomes, E.E., Thacker, J, Mitrofanov, V. P., Adhikari, R., Byer, R. L., Dumas, J.-C., Finn, L S, Marx, J., Drever, R W P, Thorne, K. S., Braginsky, V. B., Dumas, J.C, Gray, M., Matone, L., Strom, D.M., Biswas, R, Giardina, K. D., Siemens, X., Dergachev, V., Camp, J., Tokmakov, K., Rakhmanov, M, Goggin, L, Bullington, A., Echols, C, Gretarsson, A.M., Maros, E., Veitch, John, Cokelaer, Thomas, Finn, L.S., Giardina, K D, Brown, D.A., Wilkinson, C., Burmeister, O, Pedraza, M, Moreno, G., Goetz, E, Zotov, N, Chelkowski, S., Van Den Broeck, C, Mercer, R., Keppel, D G, Katsavounidis, E., Ruet, L., Plissi, M.V., Mittleman, R., Radkins, H., Taylor, R., Zanolin, M., Adhikari, R, Sarin, P, Kissel, J., McGuire, S C, Sibley, A, Willems, P A, Kozak, D., MacInnis, M, Yakushin, I., Smith, N.D., Waldman, S.J., Clark, D., Lam, P.K., Bogue, L, Lockerbie, N A, Principe, M., Sengupta, Anand Sankar, Stone, R., Huttner, S., Zucker, M, Gholami, I, Kozhevatov, I., Klimenko, S., Bastarrika, M., Jones, R., Goda, K, Wilkinson, C, Summerscales, T. Z., Hoak, D., Black, E, Stochino, A., Smith, J.R., Gouaty, R, Sintes, A M, Markowitz, J., Garofoli, J., Saraf, S., Shoemaker, D., Overmier, H, Keppel, D., Gholami, I., Newton, G., Trias, M., Vyatchanin, S P, Somiya, K., Lei, M., Heefner, J, Wette, K., Strain, K., Sannibale, V., Brinkmann, M., Mitrofanov, V P, Buonanno, A., Heng, I. S., Martin, I., Whiting, B.F., Barker, D, Yan, Z., Barker, C, Jones, Gareth, Giardina, K., Beyersdorf, P., Sun, K., Heng, I., Schnabel, R., Sato, S, Beyersdorf, P T, Kasprzyk, D., Desai, S., Weinstein, Alan J., Sintes, A.M., Cardenas, L, Plissi, M., Overmier, H., Abbott, B., Rowan, S., Whiting, B., Mandic, V, Kim, C, Vorvick, C, Barriga, P, van der Sluys, M., Braginsky, V., Stein, L.C., Kondrashov, V, Guenther, M., Aufmuth, P., Schwinberg, P, Ryan, K, Danzmann, K., Dalrymple, J., Moreno, G, Pan, Y, Savage, R, Gonzlez, G., Chen, Y, Ajith, Parameswaran, Wu, W., Grant, A., Mageswaran, M., Nash, T., Brooks, A, Barker, C., Sellers, D, Allen, G., Gossler, S., Dwyer, J.G., McKenzie, K., Sutton, P.J., Wipf, C., Araya, M., Hanna, C, Goda, K., Gretarsson, A., Miller, J, Martin, R M, Smith, M. R., Kozhevatov, I, Barker, D., Hammer, D, Goggin, L., Drever, R., Muller-Ebhardt, H., Frey, R, Vecchio, A., Whelan, J., Patel, P, Kawabe, K., Sinha, S, Lei, M, Doomes, E. E., Goetz, E., Dwyer, J G, Williams, H. R., Hayama, K, Ivanov, A., Lucianetti, A, Krishnan, B, Savov, P., Prix, R., Hewitson, M., O'Shaughnessy, R., Wilmut, I, Radkins, H, Brau, J.E., Gras, S, Kalogera, V., Dwyer, J., Landry, M, Cannon, K., Gretarsson, A. M., Arain, M. A., Urbanek, K, Degallaix, J., Fan, Y., Brunet, G, Yamamoto, H., Thüring, A, Mercer, R. A., Kokeyama, K, Evans, T., Boschi, V., Bayer, K, Brinkmann, M, Kells, W., Romano, Joseph David, Wilmut, I., Mailand, K., Bantilan, H., Khalili, F.Y., Romano, J.D., Ramsunder, M, Urbanek, K., Hild, S, Creighton, J. D. E., Plissi, M V, Sorazu, B., Wallace, L, Mendell, G., Allen, B., Vaulin, R, Lindquist, P., Smith, M.R., Fricke, T., Rainer, N., Gustafson, R, Samidi, M., Leindecker, N, Cumming, A, Giaime, J., Rabeling, D S, Lantz, B., Smith, J R, Davies, G., Matone, L, Rudiger, A., Papa, M., Bork, R., Wipf, C. C., Villar, A, Waldman, S J, Blackburn, K., Willems, P.A., Anderson, S B, Lam, P K, Shoemaker, D. H., Summerscales, T Z, Meshkov, S., Wiseman, A G, Ottaway, D., Yakushin, I, Reitze, D.H., Weiss, R, Johnson, W. W., Route, R, Pinto, I.M., Bantilan, H, Braginsky, V.B., Robertson, N. A., Gouaty, R., Rodriguez, A, Searle, A., Ajith, P., Torrie, C., Freise, A., Schutz, B. F., Khalili, F. Ya, Summerscales, T.Z., Shoemaker, D.H., Vyatchanin, S. P., Johnson, B., Casebolt, T., Greenhalgh, R. J. S., Ottens, R.S., Lindquist, P, Romie, J, Pletsch, H., Lin, H., Woan, G., Billingsley, G., Pletsch, H. J., Abbott, R, Brady, P.R., Zanolin, M, Babak, S., Clark, J., Kwee, P, McClelland, D E, Schnabel, R, Byer, R.L., Roddy, S., Cagnoli, G, Waldman, S., Sato, S., Arain, M., Abbott, B, Zucker, M., Mukherjee, S., Pan, Y., Babak, S, Betzwieser, J, Stone, R, Bork, R, Dupuis, R. J., Aufmuth, P, Hough, J., Libbrecht, K, Hallam, J., Cook, D, Grant, A, Vorvick, C., Arain, M A, Cokelaer, T, Messenger, C.J., Willke, B, Saulson, P R, Kissel, J.S., Conte, R, Fairhurst, S, Betzwieser, J., Rehbein, H., Hild, S., Kanner, J., Hage, B., Ottens, R S, Barriga, P., Bilenko, I A, Landry, M., Leonor, I., Sung, M, Anderson, W. G., Hewitson, M, Meyers, D, Sun, K.-X., Robinson, E., Grunewald, S., Woan, G, Smith, N., Greenhalgh, R., Lu, P. +999 morecore +1 more source机械摆供货系统的反馈机构设计计算
Jixie chuandong, 2007 The method of parameter calculation for a mechanical feedback organization is presented. It can be used to design a feedback organization of a mechanical pendulum for offering freight system.赖雅琳doaj Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller +16 morewiley +1 more source
