Results 71 to 80 of about 164,242 (252)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Design and fabrication of a micromachined electrostatically suspended gyroscope [PDF]

, 2008
The current paper describes the design and fabrication of a micromachined electrostatically suspended gyroscope. Electrostatic levitation is employed to suspend the rotor, eliminating the mechanical bearing and thus friction effects between the rotor and
Damrongsak, B, Kraft, M, Kraft, Michaël, Rajgopal, S, Mehregany, M., Damrongsak, B., Mehregany, M, Damrongsak, Badin, Rajgopal, S.   +8 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Pulsed Digital Oscillators for Electrostatic MEMS [PDF]

, 2012
This paper introduces a new actuation scheme for implementing Pulsed Digital Oscillators (PDOs) for electrostatic MEMS resonators. In this scheme, the capacitance of the device is biased with a voltage and it is periodically sampled. Short pulses of zero
Pons Nin, Joan, Blokhina, Elena, Madrenas, J., Gorreta, Sergi, Gorreta Mariné, Sergio, Domínguez Pumar, Manuel, O'Connell, Diarmuid, Feely, Orla, Dominguez, Manuel, Jiménez Serres, Vicente, Ruiz Fernández, Daniel, Madrenas Boadas, Jordi, Fernandez, D., O\u27Connell, Diarmuid, O'Connell, D., Jimenez, V.   +15 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Feedback control of unsupported standing in paraplegia. Part I: optimal control approach [PDF]

, 1997
This is the first of a pair of papers which describe an investigation into the feasibility of providing artificial balance to paraplegics using electrical stimulation of the paralyzed muscles. By bracing the body above the shanks, only stimulation of the
Hunt, K.J., Donaldson, N., Munih, M.
core  

A Survey of Underactuated Mechanical Systems [PDF]

, 2013
Peer ...
Yu, Hongnian, Liu, Yang
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Evaluating user response to in-car haptic feedback touchscreens using the Lane Change Test [PDF]

, 2012
Touchscreen interfaces are widely used in modern technology, from mobile devices to in-car infotainment systems. However, touchscreens impose significant visual workload demands on the user which have safety implications for use in cars. Previous studies
Pitts, Matthew J., Skrypchuk, Lee, Mark A. Williams, Lee Skrypchuk, Alex Attridge, Matthew J. Pitts, Attridge, Alex, Williams, M. A. (Mark A.), Tom Wellings, Wellings, Tom   +9 more
core   +1 more source

Almost Global Stabilization of Curvature-Nullifiable Mechanical Systems via Pure Mechanical Feedback

Applied Sciences
Mechanical control systems structure, derived from Euler–Lagrange dynamics, is directly tied to physically meaningful coordinates such as joint angles, positions, and velocities. This work investigates when a mechanical control system can be transformed,
Marta Drążkowska, Marcin Nowicki
doaj   +1 more source