Results 71 to 80 of about 3,578,319 (247)

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

open access: yesMolecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan   +8 more
wiley   +1 more source

Choosing methods and metrics for design feedback

open access: yes, 2019
Thesis: S.B., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2019Cataloged from PDF version of thesis.Includes bibliographical references (pages 18-19).Collecting feedback is an invaluable part of the design process because ...
Steindl, Riley M.
core  

The multifaceted roles of lysosomes in cancer

open access: yesMolecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Computation within the context of mechanical engineering at MIT

open access: yes, 2019
Thesis: S.B., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2019Cataloged from the official PDF of thesis. "May 2019."Computation is undoubtedly playing a significant role in mechanical engineering both inside and outside ...
Lee, Kyubin (Researcher in mechanical engineering).
core  

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

open access: yesMolecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi   +2 more
wiley   +1 more source

Computing muscle mechanical state variables from combined proprioceptive sensory feedback

open access: yesExperimental Physiology
Proprioceptive sensory feedback is crucial for the control of movement. In many ways, sensorimotor control loops in the neuromuscular system act as state feedback controllers.
Jacob D. Stephens   +2 more
doaj   +1 more source

Short structured feedback training is equivalent to a mechanical feedback device in two-rescuer BLS: a randomised simulation study. [PDF]

open access: yes, 2016
BACKGROUND Resuscitation guidelines encourage the use of cardiopulmonary resuscitation (CPR) feedback devices implying better outcomes after sudden cardiac arrest. Whether effective continuous feedback could also be given verbally by a second rescuer (
Breckwoldt, Jan   +26 more
core   +2 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Noise suppression of on-chip mechanical resonators by chaotic coherent feedback

open access: yes, 2015
We propose a method to decouple the nanomechanical resonator in optomechanical systems from the environmental noise by introducing a chaotic coherent feedback loop. We find that the chaotic controller in the feedback loop can modulate the dynamics of the
Zhang, Jing   +7 more
core  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

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