Results 51 to 60 of about 7,825,017 (274)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Characteristics of bone structural changes by growth and mechanical stress in growing rats

Journal of Physical Fitness and Sports Medicine, 2014
Cortical bone is porous in infants but compacts with growth. In that process, circumferential lamellae are formed on the endosteum (inner) side of cortical bone first, and also the periosteum (exterior) side, after that.
Masafumi Ohsako, Tsuyoshi Morita, Satoshi Inoue, Masato Takahashi   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Research Progress on the Regulation of Growth Plate Endochondral Ossification by Mechanical Loading

Xiehe Yixue Zazhi
The endochondral ossification of the growth plate is crucial for the longitudinal growth of long bones. Mechanical loading plays an important regulatory role in endochondral ossification.
GUO Xiaoyuan, SUN Yuxin, WANG Yutong, CHEN Shi, PAN Hui   +4 more
doaj   +1 more source

Regulatory Role of Cell Division Rules on Tissue Growth Heterogeneity

Frontiers in Plant Science, 2012
The coordination of cell division and cell expansion are critical to normal development of tissues. In plants, cell wall mechanics and the there from arising cell shapes and mechanical stresses can regulate cell division and cell expansion and thereby ...
Karen Alim, Olivier Hamant, Arezki Boudaoud   +2 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

A Mechanical Theory of Growth

Journal of Elasticity
AbstractA theory of growth is developed, utilizing the notion of a directional density function that captures the number and distribution of the material particles and their changes in time. A spatial (or Eulerian) description of kinematics is adopted, and the constitutive theory for a growing body is developed that relates the stress to the ...
openaire   +2 more sources

Mechanical growth and morphogenesis of seashells [PDF]

Journal of Theoretical Biology, 2012
Seashells grow through the local deposition of mass along the aperture. Many mathematical descriptions of the shapes of shells have been provided over the years, and the basic logarithmic coiling seen in mollusks can be simulated with few parameters.
Moulton, D.E., Goriely, A., Chirat, R.
openaire   +7 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source