Results 41 to 50 of about 1,797,968 (302)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács   +8 more
wiley   +1 more source

Integrating green hydrogen into building-distributed multi-energy systems with water recirculation

open access: yesApplications in Energy and Combustion Science
This study proposes integrating a building-distributed multi-energy system (BDMES) with green hydrogen to decarbonise electricity generation for buildings. By producing and consuming green hydrogen locally at the building site, using a water electrolyser
Hanhui Lei   +5 more
doaj   +1 more source

Direct Graphene Growth on Insulator [PDF]

open access: yes, 2011
Fabrication of graphene devices is often hindered by incompatibility between the silicon technology and the methods of graphene growth. Exfoliation from graphite yields excellent films but is good mainly for research.
Dabrowski, Jarek   +5 more
core   +2 more sources

Mechanical feedback coordinates cell wall expansion and assembly in yeast mating morphogenesis. [PDF]

open access: yesPLoS Computational Biology, 2018
The shaping of individual cells requires a tight coordination of cell mechanics and growth. However, it is unclear how information about the mechanical state of the wall is relayed to the molecular processes building it, thereby enabling the coordination
Samhita P Banavar   +5 more
doaj   +1 more source

A chain mechanism for flagellum growth [PDF]

open access: yesNature, 2013
Bacteria swim by means of long flagella extending from the cell surface. These are assembled from thousands of protein subunits translocated across the cell membrane by an export machinery at the base of each flagellum. Unfolded subunits then transit through a narrow channel at the core of the growing flagellum to the tip, where they crystallize into ...
Evans, Lewis DB   +4 more
openaire   +3 more sources

The role of topology and mechanics in uniaxially growing cell networks [PDF]

open access: yes, 2020
In biological systems, the growth of cells, tissues, and organs is influenced by mechanical cues. Locally, cell growth leads to a mechanically heterogeneous environment as cells pull and push their neighbors in a cell network.
Erlich, Alexander   +4 more
core   +2 more sources

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel   +3 more
wiley   +1 more source

Effects of reduced chemical application by mechanical-chemical synergistic weeding on maize growth and yield in East China

open access: yesFrontiers in Plant Science, 2022
There is growing concern about the environmental impact of chemicals and the long-term effects of mechanical weeding, which inhibits weed regrowth. Mechanical-chemical synergy has become an alternative weeding practice.
Huimin Fang   +5 more
doaj   +1 more source

Pulmonary Dysfunction Is Associated With Sleep Study Abnormalities in Children With Sickle Cell Disease: A Multicenter Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Pulmonary dysfunction and sleep abnormalities are common in children with sickle cell disease (SCD) and are associated with worse clinical outcomes. Whether spirometry abnormalities are associated with polysomnography (PSG) findings remains unclear.
Ammar Saadoon Alishlash   +4 more
wiley   +1 more source

Intelligent lithium plating detection and prediction method for Li-ion batteries based on random forest model

open access: yesGreen Energy and Intelligent Transportation
Lithium plating in lithium-ion batteries (LIBs) is one of the main causes of safety accidents in electric vehicles (EVs). The study of intelligent machine learning-based lithium plating detection and warning algorithms for LIBs is of great importance ...
Guangying Zhu   +7 more
doaj   +1 more source

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