Results 131 to 140 of about 29,278,787 (347)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Application and Node Mechanics Analysis of Sucker Rod Pump Injection-production System

Shiyou jixie, 2017
To achieve effective production stabilization and water-cut control in extra-high water-cut wells, a sucker rod pump injection-production system has been designed. The system uses gravity to separate the oil and water in the downhole. The separated water
Jiang Minzheng, Duan Tianyu, Liu Jintang, Zhang Huaiyu   +3 more
doaj  

Failure depths of stope floors under dynamic loading induced by roof breaking

Meitian dizhi yu kantan
ObjectiveAccurately assessing the failure depths of stope floors is crucial for assessing floor water inrush risks. Conventional theoretical models for calculating the failure depths generally merely consider static loads from the support pressure and ...
Qisong HUANG, Bo XU, Junjun FENG, Xiaofei LIN, Jiulong CHENG, Jun PENG   +5 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Characterization of Hydraulic Spool Clamping Triggered by Solid Particles Based on Mechanical Model and Experiment Research

Applied Sciences
Hydraulic spool valves may clamp under the action of sensitive particles when working in hydraulic oils that contain solid particles, which will then bring about a devastating detriment to the machines.
Qianpeng Chen, Min Liu, Hong Ji, Wenwei Chai, Changmin Luo   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Stability Analysis of Subsea Wellhead Oil Control Device

Shiyou jixie, 2016
To ensure the subsea wellhead rescue oil control device do not experience instability during switching operation,a reasonable in-mud depth of the oil control device need to be determined.In view of this,the mechanical model of the subsea wellhead oil ...
Li Zhigang, Li Chunsheng, Shang Xianchao, Wang Liquan, Cao Man, Lu Guanbo   +5 more
doaj  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source