Results 141 to 150 of about 27,702,308 (366)

Set-based design of mechanical systems with design robustness integrated

, 2014
This paper presents a method for parameter design of mechanical products based on a set-based approach. Set-based concurrent engineering emphasises on designing in a multi-stakeholder environment with concurrent involvement of the stakeholders in the ...
DANTAN, Jean-Yves, Bigot, Régis, QURESHI, Ahmed Jawad, BRUYERE, Jérôme   +3 more
core   +1 more source

Load Analysis and Calculation of Makeup and Breakout Device on Continuous Circulation System

Shiyou jixie, 2019
The makeup and breakout device is a key component of the continuous circulation system. To rationally design the makeup and breakout device on the continuous circulation system, the working principle and operation procedure are analyzed. According to the
Hu Zhijian, Ma Qingfang, Liu Jiliang
doaj  

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Application and Node Mechanics Analysis of Sucker Rod Pump Injection-production System

Shiyou jixie, 2017
To achieve effective production stabilization and water-cut control in extra-high water-cut wells, a sucker rod pump injection-production system has been designed. The system uses gravity to separate the oil and water in the downhole. The separated water
Jiang Minzheng, Duan Tianyu, Liu Jintang, Zhang Huaiyu   +3 more
doaj  

Failure depths of stope floors under dynamic loading induced by roof breaking

Meitian dizhi yu kantan
ObjectiveAccurately assessing the failure depths of stope floors is crucial for assessing floor water inrush risks. Conventional theoretical models for calculating the failure depths generally merely consider static loads from the support pressure and ...
Qisong HUANG, Bo XU, Junjun FENG, Xiaofei LIN, Jiulong CHENG, Jun PENG   +5 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Characterization of Hydraulic Spool Clamping Triggered by Solid Particles Based on Mechanical Model and Experiment Research

Applied Sciences
Hydraulic spool valves may clamp under the action of sensitive particles when working in hydraulic oils that contain solid particles, which will then bring about a devastating detriment to the machines.
Qianpeng Chen, Min Liu, Hong Ji, Wenwei Chai, Changmin Luo   +4 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Stability Analysis of Subsea Wellhead Oil Control Device

Shiyou jixie, 2016
To ensure the subsea wellhead rescue oil control device do not experience instability during switching operation,a reasonable in-mud depth of the oil control device need to be determined.In view of this,the mechanical model of the subsea wellhead oil ...
Li Zhigang, Li Chunsheng, Shang Xianchao, Wang Liquan, Cao Man, Lu Guanbo   +5 more
doaj  

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source