Results 121 to 130 of about 29,278,787 (347)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Cause Analysis of Rod Parting Based on Polished Rod Load
Shiyou jixieAt present,the rod parting research mainly focuses on the mechanism analysis after parting,with less involvement in parting prevention.The fault diagnosis of downhole working conditions mostly relies on indicator diagrams,which cannot diagnose the ...
吕萌萌 +6 more
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A method of vulnerability assessment for power communication network based on mechanical model
Dianxin kexue, 2019 In order to reasonably evaluate the vulnerability of the power communication network link, a vulnerability assessment method based on the mechanical model was proposed.
Yaosheng WANG, Yingmin ZHANG, Chang WANG
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Frontiers in MedicineMechanical strain plays a significant role in lung pathophysiology. Current two-dimensional (2D) in vitro models fail to capture the lung's dynamic mechanical environment.
Safiya Al Yazeedi +10 more
doaj +1 more source
Two-Stage Discrete Mechanical Modelin Three-Dimensional Spacefor Garmentsimulation
AUTEX Research Journal, 2019 This paper focuses on the better performance between the garment simulation result and the simulation speed. For simplicity and clarity, a notation “PART” is defined to indicate the areas between the garment and the human body satisfying some constraints.
Luo Xuan, Jiang Gaoming, Cong Honglian
doaj +1 more source
Mechanical model of nanoparticles for material removal in chemical mechanical polishing process
, 2016 Chemical mechanical polishing (CMP) is the most effective method for surface planarization in the semiconductor industry. Nanoparticles are significant for material removal and ultra-smooth surface formation.
Hao Chen, D. Guo, G. Xie, G. Pan
semanticscholar +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Modeling of human center of pressure using a viscoelastic-supported inverted pendulum
Mechanical Engineering JournalPreventing falls is crucial for the elderly, and as an initial step, accurately quantifying their current balance abilities is essential. In this regard, the Center of Pressure (COP) has gained attention.
Yoshikazu YAMANAKA, Katsutoshi YOSHIDA
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Load Analysis and Calculation of Makeup and Breakout Device on Continuous Circulation System
Shiyou jixie, 2019 The makeup and breakout device is a key component of the continuous circulation system. To rationally design the makeup and breakout device on the continuous circulation system, the working principle and operation procedure are analyzed. According to the
Hu Zhijian, Ma Qingfang, Liu Jiliang
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