Results 161 to 170 of about 27,702,308 (366)
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
Magneto-Mechanical Model of an Enzyme
The Chemical Educator, 2002 It has always been difficult to clearly explain to biochemistry students how enzymes work. The idea of enzyme–substrate stereospecificity, active site, coupled reactions, inhibitor or activator effects, mono- and bisubstrate reactions or any other aspect related to the mechanism of action of enzymes are in general abstract and difficult concepts for ...
openaire +2 more sources
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and optimization of an Magnetohydrodynamic energy harvester for intelligent pipe systems
, 2019 Thesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, June, 2019Cataloged from PDF version of thesis.Includes bibliographical references (pages 115-118).In this thesis, an innovative Magnetohydrodynamic (MHD) energy ...
Zhang, Xiaotong(Mechanical engineer).
core
Musculoskeletal Mechanics and Modeling
Scholarpedia, 2016 Gerald E. Loeb, Rahman Davoodi
openaire +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
A mechanical model of muscle mechanics
, 2009 The thesis describes the skeletal muscle contraction from a purely (micro)mechanical point of view. The fast time scale processes related to the power stroke event is firstly described as diffusion in a non-convex energy which leads to an overcoming of some drawbacks of the classical Huxley and Simmons model. The new model allows the description of the
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FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source